Evidence map›Paper›PMID 25530846›Full record

ArticleRSC advances2014

Central C-C Bonding Increases Optical and Chemical Stability of NIR Fluorophores.

Hoon Hyun, Eric A Owens, Lakshminarayana Narayana, Hideyuki Wada, Julien Gravier, Kai Bao, John V Frangioni, Hak Soo Choi, Maged Henary

Abstract read
In one paragraph

Article in RSC advances, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Trial
  2. More Than a Glow: How Cyanine Dyes Shape Tracer Pharmacokinetics.Angewandte Chemie (International ed. in English) · 2026
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  8. Lysosome-Targeted Bifunctional Therapeutics Induce Autodynamic Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. HSA-ZW800-PEG for Enhanced Optophysical Stability and Tumor Targeting.International journal of molecular sciences · 2023
    Article
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  11. Article
  12. Article
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  14. Article
  15. Article
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  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hoon HyunDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
Eric A OwensDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 3030.
Lakshminarayana NarayanaDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 3030.
Hideyuki WadaDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
Julien GravierDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
Kai BaoDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
John V FrangioniDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215 ; Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215 ; Curadel, LLC, 377 Plantation Street, Worcester, MA 01605, USA.
Hak Soo ChoiDivision of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
Maged HenaryDepartment of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 3030.

Funding

Intraoperative Near-Infrared Fluorescence ImagingR01CA115296 · NCI · CURADEL, LLC · PI FRANGIONI, JOHN V · 2005 to 2014
$13.9M
Ultra-Low Background NIR Fluorophores for In Vivo Imaging and Image-Guided SurgerR01EB010022 · NIBIB · CURADEL, LLC · PI FRANGIONI, JOHN V · 2010 to 2013
$2.8M
Image-Guided Surgery of Endocrine Glands and Their Tumors using Near-Infrared FluR01EB011523 · NIBIB · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHOI, HAK SOO · 2010 to 2013
$2.0M
NCI NIH HHS R01 CA115296NIBIB NIH HHS R01 EB010022NIBIB NIH HHS R01 EB011523
6 · The paper itself

Abstract

Functional near-infrared (NIR) fluorophores have played a major role in the recent advances in bioimaging. However, the optical and physicochemical stabilities of NIR fluorophores in the biological and physiological environment are still a challenge. Especially, the ether linkage on the

Indexed as

Image-Guided SurgeryNear-Infrared FluorescenceOptical ImagingSignal-to-Background RatioSuzuki-coupling

Identifiers

PMID25530846
PMCPMC4267294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.