ArticleBiology of mood & anxiety disorders2014
Aberrant amygdala functional connectivity at rest in pediatric anxiety disorders.
Article in Biology of mood & anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Altered amygdala resting-state functional connectivity in anxiety disorders: a coordinate-based meta-analysis.Psychological medicine · 2026Pooled it
- A systematic review and meta-analysis of resting-state fMRI in anxiety disorders: Need for data sharing to move the field forward.Journal of anxiety disorders · 2023Pooled it
- Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging.NeuroImage. Clinical · 2019Pooled it
- Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial.Cognitive, affective & behavioral neuroscience · 2023Trial
- Functional connectivity during positive mood and anxiety treatment response in children.Journal of affective disorders · 2026Article
- Childhood gut microbiome is linked to internalizing symptoms at school age via the functional connectome.Nature communications · 2025Observational
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Socioeconomic factors, sleep timing and duration, and amygdala resting-state functional connectivity in children.Frontiers in psychiatry · 2024Article
- Shared and distinct biological mechanisms for anxiety and sensory over-responsivity in youth with autism versus anxiety disorders.Journal of neuroscience research · 2024Article
- Novel mechanism-based treatments for pediatric anxiety and depressive disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Structural brain network topological alterations in stuttering adults.Brain communications · 2022Article
- Article
- Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children.Brain communications · 2022Article
- Reversed patterns of resting state functional connectivity for females vs. males in posttraumatic stress disorder.Neurobiology of stress · 2021Article
- Microstructure of the Dorsal Anterior Cingulum Bundle in Very Preterm Neonates Predicts the Preterm Behavioral Phenotype at 5 Years of Age.Biological psychiatry · 2021Article
- Dynamic Functional Connectivity Reveals Abnormal Variability in the Amygdala Subregions of Children With Attention-Deficit/Hyperactivity Disorder.Frontiers in neuroscience · 2021Article
- Illness Severity Moderated Association Between Trait Anxiety and Amygdala-Based Functional Connectivity in Generalized Anxiety Disorder.Frontiers in behavioral neuroscience · 2021Article
- The Self and its World: A Neuro-Ecological and Temporo-Spatial Account of Existential Fear.Clinical neuropsychiatry · 2020Article
- Imaging the socially-anxious brain: recent advances and future prospects.F1000Research · 2020Review
- Associations between Amygdala-Prefrontal Functional Connectivity and Age Depend on Neighborhood Socioeconomic Status.Cerebral cortex communications · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundChildhood onset of anxiety disorders is associated with greater functional impairment and burden across the lifespan. Recent work suggests that generalized anxiety disorder (GAD) is characterized by dysfunctional connectivity in amygdala-based circuits at rest in adolescents, consistent with adults. However, neural mechanisms underlying a broad spectrum of often-comorbid anxiety disorders in children remains unclear and understudied. The current study examines amygdala functional connectivity at rest in children and adolescents across comorbid anxiety disorders (ADs) including youth with primary diagnoses of GAD and social phobia (SP).
resultsCompared with healthy controls (HCs), AD youth exhibited hyperconnectivity between the right amygdala and the insula and hypoconnectivity between the left amygdala and the ventromedial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC). Within the AD group, connectivity was not correlated with anxiety severity and only the amygdala-PCC connectivity was positively correlated with age.
conclusionsOur findings indicate that youth with comorbid ADs demonstrate aberrant connectivity in the anterior limbic network (ALN) as well as the PCC at rest. This extends upon previous work suggesting alterations in amygdala circuits underlying fear learning, emotion regulation, and the processing of interoceptive states. Presence of these findings within this young, comorbid sample points to underlying common mechanisms across ADs and illuminates future targets for prevention and intervention in childhood.
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