ArticleEvidence-based complementary and alternative medicine : eCAM2014
Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Sepsis secondary to co-infection with malaria, dengue and COVID-19: a case report.BMC infectious diseases · 2026Article
- Various parts ofFrontiers in molecular biosciences · 2026Review
- Acute Toxicity and Antihyperlipidemic Effects of Syringaldehyde with Downregulation of SREBP-2 Gene Expression in Rats.ACS omega · 2025Article
- Non-clinical safety evaluation of Yongdamsagan-tang water extract: A 13-week subchronic oral toxicity study in Sprague Dawley rats.Journal of applied toxicology : JAT · 2025Article
- An Ethnobotanical Survey and Pharmacological and Toxicity Review of Medicinal Plants Used in the Management of Obesity in the North Central Zone of Nigeria.Journal of obesity · 2025Article
- Safety of OralToxics · 2024Article
- Phytochemical Extract from Carica papaya Leaves and Punica granatum Seeds as Therapy Against Cognitive Impairment in a Murine Model.Molecular neurobiology · 2024Article
- Pre-clinical protective potentials ofAmerican journal of translational research · 2024Article
- Potential Plant-Based New Antiplasmodial Agent Used in Papua Island, Indonesia.Plants (Basel, Switzerland) · 2023Review
- A review of efficacy and safety of Ugandan anti-malarial plants with application of RITAM score.Malaria journal · 2023Review
- Article
- Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Review
- Article
- Dengue Fever: Therapeutic Potential ofFrontiers in pharmacology · 2021Review
- Therapeutic application of Carica papaya leaf extract in the management of human diseases.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Review
- Preliminary study on the expression of endothelial cell biology related genes in the liver of dengue virus infected mice treated with Carica papaya leaf juice.BMC research notes · 2019Article
- Effect of freeze-dried Carica papaya leaf juice on inflammatory cytokines production during dengue virus infection in AG129 mice.BMC complementary and alternative medicine · 2019Article
- The effect of freeze-dried Carica papaya leaf juice treatment on NS1 and viremia levels in dengue fever mice model.BMC complementary and alternative medicine · 2018Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The subchronic toxicity effect of the leaf extract of Carica papaya Linn. in Sprague Dawley (SD) rats was investigated in this study. The extract was prepared by dissolving the freeze dried extract of the leaves in distilled water and was administered orally to SD rats (consisted of 10 rats/sex/group) at 0 (control), 0.01, 0.14, and 2 g/kg body weight (BW) for 13 weeks. General observation, mortality, and food and water intake were monitored throughout the experimental period. Hematological and biochemical parameters, relative organ weights, and histopathological changes were evaluated. The study showed that leaf extract when administered for 13 weeks did not cause any mortality and abnormalities of behavior or changes in body weight as well as food and water intake. There were no significant differences observed in hematology parameters between treatment and control groups; however significant differences were seen in biochemistry values, for example, LDH, creatinine, total protein, and albumin. However, these changes were not associated with histopathological changes. In conclusion, the results suggested that daily oral administration of rats with C. papaya leaf extract for 13 weeks at a dose up to fourteen times the levels employed in traditional medicine practice did not cause any significant toxic effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.