Evidence map›Paper›PMID 25530742›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2014

Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension.

Gary J Patti, Ralf Tautenhahn, Darcy Johannsen, Ewa Kalisiak, Eric Ravussin, Jens C Brüning, Andrew Dillin, Gary Siuzdak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. The metabolic contribution of SKN-1/Nrf2 to the lifespan of Caenorhabditis elegans.Metabolomics : Official journal of the Metabolomic Society · 2023
    Article
  2. Helminth lipidomics: Technical aspects and future prospects.Current research in parasitology & vector-borne diseases · 2021
    Review
  3. Identification of bioactive metabolites using activity metabolomics.Nature reviews. Molecular cell biology · 2019
    Review
  4. Article
  5. Article
  6. Emerging Omics Approaches in Aging Research.Antioxidants & redox signaling · 2018
    Review
  7. Article
  8. Lipidomic Analysis ofBio-protocol · 2017
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Gary J PattiDepartments of Chemistry, Genetics, and Medicine, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8232, St. Louis, MO 63110, USA.
Ralf TautenhahnDepartments of Chemistry and Molecular Biology, The Center for Mass Spectrometry and Metabolomics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Darcy JohannsenHuman Physiology, The Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Ewa KalisiakDepartments of Chemistry and Molecular Biology, The Center for Mass Spectrometry and Metabolomics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Eric RavussinHuman Physiology, The Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Jens C BrüningDepartment of Mouse Genetics and Metabolism, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), Institute for Genetics and Center for Molecular Medicine, University of Cologne (CMMC), Zülpicher Str. 47, 50674 Cologne, Germany.
Andrew DillinHoward Hughes Medical Institute, Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Gary SiuzdakDepartments of Chemistry and Molecular Biology, The Center for Mass Spectrometry and Metabolomics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA.
Scripps Research Institute · USPennington Biomedical Research Center · USCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEHoward Hughes Medical Institute · USWashington University in St. Louis · US

Funding

Therapeutics Core (Page 286)P30MH062261 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2000 to 2021
$37.7M
Adult Stem Cells for Therapy of Visual DisordersR24EY017540 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI FRIEDLANDER, MARTIN · 2007 to 2011
$17.5M
Neuroendocrine Coordination of Mitochondrial Stress Signaling and ProteostasisR01ES021667 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DILLIN, ANDREW G · 2012 to 2023
$4.6M
Proteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS SynergyP01DA026146 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GENDELMAN, HOWARD E · 2008 to 2010
$2.9M
Normalizing Breast Cancer Metabolism to Prevent Progression and Recurrence (PQ21)R01CA170737 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI FELDING, BRUNIE H. · 2012 to 2015
$2.1M
DEVELOPING THE UNTARGETED METABOLOMIC WORKFLOW FOR HIGH-THROUGHPUT ANALYSESR01ES022181 · NIEHS · WASHINGTON UNIVERSITY · PI PATTI, GARY J · 2012 to 2016
$1.8M
NCI NIH HHS R01 CA170737NEI NIH HHS R24 EY017540NIA NIH HHS L30 AG038036NIDA NIH HHS P01 DA026146NIEHS NIH HHS R01 ES021667NIEHS NIH HHS R01 ES022181NIMH NIH HHS P30 MH062261
6 · The paper itself

Abstract

The manipulation of distinct signaling pathways and transcription factors has been shown to influence life span in a cell-non-autonomous manner in multicellular model organisms such as

Indexed as

AgingC. elegansMeta-analysisMetabolismMetabolomicsSarcopenia

Identifiers

PMID25530742
PMCPMC4267291
OpenAlexW1977713552

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.