Evidence map›Paper›PMID 25530736›Full record

ArticleJournal of the International Society of Sports Nutrition2014

Amino acid supplementation and impact on immune function in the context of exercise.

Vinicius Fernandes Cruzat, Maurício Krause, Philip Newsholme

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Society of Sports Nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04642716 (Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease), which is not on this map. Cited by 59 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04642716 nacompletednot on this mapstarted 2015, after this paper: background citation

Evaluation of Free Aminoacids in Saliva as A Diagnostic Biomarker of Periodontal Disease

TypeinterventionalSponsorIstanbul Medipol University HospitalRan2015 to 2017Enrolled60ConditionsPeriodontitis, Diagnoses DiseaseArmsSaliva collection of patients and salivary free amino acids analysis
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vinicius Fernandes CruzatCHIRI Biosciences Research Precinct, Faculty of Health Sciences, School of Biomedical Sciences, Curtin University, GPO Box U1987, Perth, Western Australia Australia.
Maurício KrauseLaboratory of Cellular Physiology, Department of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS Brazil.
Philip NewsholmeCHIRI Biosciences Research Precinct, Faculty of Health Sciences, School of Biomedical Sciences, Curtin University, GPO Box U1987, Perth, Western Australia Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Moderate and chronic bouts of exercise may lead to positive metabolic, molecular, and morphological adaptations, improving health. Although exercise training stimulates the production of reactive oxygen species (ROS), their overall intracellular concentration may not reach damaging levels due to enhancement of antioxidant responses. However, inadequate exercise training (i.e., single bout of high-intensity or excessive exercise) may result in oxidative stress, muscle fatigue and muscle injury. Moreover, during the recovery period, impaired immunity has been reported, for example; excessive-inflammation and compensatory immunosuppression. Nutritional supplements, sometimes referred to as immuno-nutrients, may be required to reduce immunosuppression and excessive inflammation. Herein, we discuss the action and the possible targets of key immuno-nutrients such as L-glutamine, L-arginine, branched chain amino acids (BCAA) and whey protein.

Indexed as

ImmunonutritionL-arginineL-glutamineL-leucineOxidative stress

Identifiers

PMID25530736
PMCPMC4272512

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.