Evidence map›Paper›PMID 25530673›Full record

ArticleApplied magnetic resonance2014

Proton-Electron Double-Resonance Imaging of pH using phosphonated trityl probe.

Wataru Takahashi, Andrey A Bobko, Ilirian Dhimitruka, Hiroshi Hirata, Jay L Zweier, Alexandre Samouilov, Valery V Khramtsov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied magnetic resonance, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. EPR Everywhere.Applied magnetic resonance · 2021
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wataru TakahashiDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Internal Medicine and Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA ; Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
Andrey A BobkoDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Internal Medicine and Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA.
Ilirian DhimitrukaDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Internal Medicine and Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA.
Hiroshi HirataDivision of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
Jay L ZweierDivision of Cardiology and Dorothy M. Davis Heart & Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Alexandre SamouilovDivision of Cardiology and Dorothy M. Davis Heart & Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Valery V KhramtsovDivision of Pulmonary, Allergy, Critical Care & Sleep Medicine, Department of Internal Medicine and Dorothy M. Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, USA.

Funding

Integration of High Field MRI and EPRI For Functional ImagingR01EB016096 · NIBIB · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2013 to 2016
$2.3M
Functional proton-electron double-resonance imaging: development and applicationR01EB014542 · NIBIB · OHIO STATE UNIVERSITY · PI KHRAMTSOV, VALERY V, SAMOUILOV, ALEXANDRE VALENTIN · 2012 to 2015
$1.3M
NIBIB NIH HHS R01 EB014542NIBIB NIH HHS R01 EB016096
6 · The paper itself

Abstract

Variable Radio Frequency Proton-Electron Double-Resonance Imaging (VRF PEDRI) enables extracting a functional map from a limited number of images acquired at pre-selected EPR frequencies using specifically designed paramagnetic probes with high quality spatial resolution and short acquisition times. In this work we explored potential of VRF PEDRI for pH mapping of aqueous samples using recently synthesized pH-sensitive phosphonated trityl radical, pTR. The ratio of Overhauser enhancements measured at each pixel at two different excitation frequencies corresponding to the resonances of protonated and deprotonated forms of pTR probe allows for a pH map extraction. Long relaxation times of pTR allow for pH mapping at EPR irradiation power as low as 1.25 W during 130 s acquisition time with spatial resolution of about 1 mm. This is particularly important for

Indexed as

Overhauser-enhanced magnetic resonance imagingPH mappingProton-Electron Double-Resonance ImagingTrityl radical

Identifiers

PMID25530673
PMCPMC4268155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.