ArticleSensors and actuators. B, Chemical2015
Spermine detection via metal-mediated ethynylarene 'turn-on' fluorescence signaling.
Article in Sensors and actuators. B, Chemical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 44 citations in OpenAlex.
- Next-Gen Point-of-Care Tool for Ultra-Sensitive Detection of Urinary Spermine for Prostate Cancer Diagnosis.ACS sensors · 2025Article
- A Bis(Acridino)-Crown Ether for Recognizing Oligoamines in Spermine Biosynthesis.Molecules (Basel, Switzerland) · 2024Article
- Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment.Biosensors · 2022Review
- Simple fluorescence optosensing probe for spermine based on ciprofloxacin-Tb3+ complexation.PloS one · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A dicarboxylated ethynylarene was shown to behave as a fluorescent chemosensor for millimolar concentrations of polyamines when mixed with Cd(II), Pb(II) or Zn(II) ions at micromolar concentrations. A bathochromic shift and intensification of fluorescence emission was observed with increasing amounts of metal ion in the presence of aqueous polyamines buffered at pH = 7.6. Such perturbations manifested as 'turn-on' signals from a ratiometric comparison of emission intensities at 390 nm versus 340 nm. Using Pb(II) as the metal mediator, spermine was selectively detected as a 40-fold signal enhancement relative to spermidine, putrescine, cadaverine and several other non-biogenic diamines. Evaluation of additional triamine and tetraamine analytes showed the influence that amine group quantity and spacing had on signal generation. By increasing the ratio of Pb(II) relative to ethynylarene, the detection limit for spermine was successfully lowered to a 25 micromolar level. Noncovalent association between ethynylarene, metal ion and polyamine are believed to promote the observed spectroscopic changes. This study exploits the subtle impact that polyamine structural identity has on transition metal chelation to define a new approach towards polyamine chemosensor development.
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Registered trials
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