Evidence map›Paper›PMID 25530501›Full record

ArticleChembiochem : a European journal of chemical biology2015

Light control of cellular processes by using photocaged abscisic acid.

Catherine W Wright, Zhi-Fo Guo, Fu-Sen Liang

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Engineering TME-gated inducible CAR-T cell therapy for solid tumors.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Split CRISPR/Cas13b System for Conditional RNA Regulation and Editing.Journal of the American Chemical Society · 2023
    Article
  10. Inducible and reversible RNA NNature communications · 2022
    Article
  11. Spatial and Temporal Control of Protein Secretion with Light.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Chemical and Light Inducible Epigenome Editing.International journal of molecular sciences · 2020
    Review
  16. Light-Induced Dimerization Approaches to Control Cellular Processes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. Optochemical Control of Biological Processes in Cells and Animals.Angewandte Chemie (International ed. in English) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Catherine W WrightDepartment of Chemistry and Chemical Biology, University of New Mexico, 300 Terrace Street NE, Albuquerque, NM 87131 (USA).
Zhi-Fo Guo
Fu-Sen Liang
University of New Mexico · US

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
NCI NIH HHS P30 CA118100
6 · The paper itself

Abstract

Abscisic acid (ABA) was chemically modified with a photocaging group to promote photo-induced protein dimerization. This photocontrolled chemically induced dimerization (CID) method based on caged ABA enables dose-dependent light regulation of cellular processes, including transcription, protein translocation, signal transduction, and cytoskeletal remodeling, without the need to perform extensive protein engineering. Caged ABA can be easily modified to respond to different wavelengths of light. Consequently, this strategy should be applicable to the design of light-regulated protein dimerization systems and potentially be used orthogonally with other light-controlled CID systems.

Indexed as

Protein MultimerizationAbscisic AcidAnimalsBenzoxazinesBiochemistryCell MembraneCHO CellsCoumarinsCricetulusGene Expression RegulationGreen Fluorescent ProteinsHEK293 CellsHumansLightLuciferasesMicroscopy, Fluorescence3,4-dihydro-3-methyl-6-nitro-2H-1,3-benzoxazin-2-oneAbscisic AcidBenzoxazinesCoumarinsenhanced green fluorescent proteinGreen Fluorescent ProteinsLuciferasesabscisic acidchemically induced dimerizationphotocagingphotochemistrysignal transduction

Identifiers

PMID25530501
PMCPMC4849874
OpenAlexW2059150443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.