ArticleEmerging infectious diseases2015
Pneumonic plague outbreak, Northern Madagascar, 2011.
Article in Emerging infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Antimicrobial Treatment and Prophylaxis of Plague: Recommendations for Naturally Acquired Infections and Bioterrorism Response.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Rapid diagnostic tests for plague.The Cochrane database of systematic reviews · 2020Pooled it
- Infectious medical waste (IMW) and disease transmission: A critical public health challenge in Africa and the global implications - A systematic review.Journal of public health research · 2026Article
- Evaluating the early diversification of Yersinia pestis and its phylogeographic expansion over 96 years of evolution in Madagascar.Communications biology · 2025Article
- First assessment of plague in terrestrial small mammals and fleas from Makira Natural Park and surroundings, North-eastern Madagascar.PLoS neglected tropical diseases · 2025Article
- Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.Microorganisms · 2024Review
- Review of genotyping methods for Yersinia pestis in Madagascar.PLoS neglected tropical diseases · 2024Review
- Characterization of two affinity matured Anti-Yersinia pestis F1 human antibodies with medical countermeasure potential.PloS one · 2024Article
- Plague Gives Surprises in the Second Decade of the Twenty-First Century.The American journal of tropical medicine and hygiene · 2023Article
- One Health: navigating plague in Madagascar amidst COVID-19.Infectious diseases of poverty · 2023Article
- Spray-Dried Inhalable Powder Formulations of Gentamicin Designed for Pneumonic Plague Therapy in a Mouse Model.Pharmaceutics · 2022Article
- Analytical framework to evaluate and optimize the use of imperfect diagnostics to inform outbreak response: Application to the 2017 plague epidemic in Madagascar.PLoS biology · 2022Article
- Stone AgeProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Transmission of Antimicrobial Resistant Yersinia pestis During a Pneumonic Plague Outbreak.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Rat Infestation in Gauteng Province: Lived Experiences of Kathlehong Township Residents.International journal of environmental research and public health · 2021Article
- Influence of Sociospatial determinants on knowledge, attitudes and practices related to the plague in a population living in endemic areas in the central highlands, Madagascar.BMC public health · 2021Article
- Plague Transmission from Corpses and Carcasses.Emerging infectious diseases · 2021Review
- Factors influencing the re-emergence of plague in Madagascar.Emerging topics in life sciences · 2020Review
- Short- and long-term humoral immune response against Yersinia pestis in plague patients, Madagascar.BMC infectious diseases · 2020Article
- Human plague: An old scourge that needs new answers.PLoS neglected tropical diseases · 2020Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yersinia pestis, the causative agent of plague, is endemic to Madagascar, particularly to the central highlands. Although plague has not been previously reported in northern Madagascar, an outbreak of pneumonic plague occurred in this remote area in 2011. Over a 27-day period, 17 suspected, 2 presumptive, and 3 confirmed human cases were identified, and all 15 untreated 20 patients died. Molecular typing of Y. pestis isolated from 2 survivors and 5 Rattus rattus rat samples identified the Madagascar-specific 1.ORI3-k single-nucleotide polymorphism genotype and 4 clustered regularly interspaced short palindromic repeat patterns. This outbreak had a case-fatality rate of 100% for nontreated patients. The Y. pestis 1.ORI3-k single-nucleotide polymorphism genotype might cause larger epidemics. Multidrug-resistant strains and persistence of the pathogen in natural foci near human settlements pose severe risks to populations in plague-endemic regions and require outbreak response strategies.
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Registered trials
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