ArticleNMR in biomedicine2015
The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease.
Article in NMR in biomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MatchingFrontiers in neuroanatomy · 2019Pooled it
- Optimized Quantitative Susceptibility Mapping at 7T MRI for Assessing Iron Deposition in Alzheimer's Disease.NMR in biomedicine · 2026Article
- Shape and texture analyses based on conventional MRI for the preoperative prediction of the aggressiveness of pituitary adenomas.European radiology · 2023Article
- The Role of Microglia in Alzheimer's Disease From the Perspective of Immune Inflammation and Iron Metabolism.Frontiers in aging neuroscience · 2022Review
- Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry.NeuroImage · 2021Article
- T2 heterogeneity as an in vivo marker of microstructural integrity in medial temporal lobe subfields in ageing and mild cognitive impairment.NeuroImage · 2021Article
- Role of Oxidative Damage in Alzheimer's Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology.Molecular psychiatry · 2020Article
- T2 heterogeneity: a novel marker of microstructural integrity associated with cognitive decline in people with mild cognitive impairment.Alzheimer's research & therapy · 2020Article
- Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction.Reviews in endocrine & metabolic disorders · 2019Review
- Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.Brain pathology (Zurich, Switzerland) · 2019Article
- Treating Alzheimer's disease by targeting iron.British journal of pharmacology · 2019Review
- Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease.Pharmaceuticals (Basel, Switzerland) · 2019Review
- Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects.Nanoscale · 2018Article
- Quantitative comparison of different iron forms in the temporal cortex of Alzheimer patients and control subjects.Scientific reports · 2018Article
- Serum Hepcidin Levels, Iron Dyshomeostasis and Cognitive Loss in Alzheimer's Disease.Aging and disease · 2017Article
- A novel approach to quantify different iron forms in ex-vivo human brain tissue.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Dysregulation of neural iron is known to occur during the progression of Alzheimer's disease. The visualization of amyloid-beta (Aβ) plaques with MRI has largely been credited to rapid proton relaxation in the vicinity of plaques as a result of focal iron deposition. The goal of this work was to determine the relationship between local relaxation and related focal iron content associated with Aβ plaques. Alzheimer's disease (n=5) and control tissue (n=3) sample slices from the entorhinal cortex were treated overnight with the iron chelator deferoxamine or saline, and microscopic gradient-echo MRI datasets were taken. Subsequent to imaging, the same slices were stained for Aβ and iron, and then compared with regard to parametric R2 * relaxation maps and gradient-echo-weighted MR images. Aβ plaques in both chelated and unchelated tissue generated MR hypo-intensities and showed relaxation rates significantly greater than the surrounding tissue. The transverse relaxation rate associated with amyloid plaques was determined not to be solely a result of iron load, as much of the relaxation associated with Aβ plaques remained following iron chelation. The data indicate a dual relaxation mechanism associated with Aβ plaques, such that iron and plaque composition synergistically produce transverse relaxation.
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