Evidence map›Paper›PMID 25529941›Full record

Trial reportHepatology (Baltimore, Md.)2015

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease.

Jeffrey B Schwimmer, Michael S Middleton, Cynthia Behling, Kimberly P Newton, Hannah I Awai, Melissa N Paiz, Jessica Lam, Jonathan C Hooker, Gavin Hamilton, John Fontanesi and 1 more

3 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hepatology (Baltimore, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 99 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 10 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02513121 nacompletednot on this map

Randomized, Controlled Dietary Treatment Study of Pediatric NAFLD

TypeinterventionalSponsorUniversity of California, San DiegoRan2015 to 2017Enrolled40ConditionsNonalcoholic Fatty Liver DiseaseArmsDietary modification
NCT02539836 nacompletednot on this map

Study on Dietary Nutrition Intervention Techniques for Children Obesity

TypeinterventionalSponsorChinese Academy of SciencesRan2015 to 2018Enrolled90ConditionsObesity, Intestinal Bacteria Flora Disturbance, Body WeightArmsDietary nutrition based on plant fermentation extract, MRI in quantifying liver fat with MRS
NCT06097039 completednot on this mapstarted 2023, after this paper: background citation

Fetuin-A, a Promising Serum Biomarker for Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)

Typeobservational_patient_registrySponsorZagazig UniversityRan2023 to 2024Enrolled100ConditionsNon-Alcoholic Fatty Liver DiseaseArmsabdominal U/S, Fibroscan with Controlled Attenuated Parameter (CAP scan):
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 10 syntheses or guidelines pooled it, 168 citations in OpenAlex.

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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jeffrey B SchwimmerDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA.
Michael S MiddletonLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA.
Cynthia BehlingDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA.
Kimberly P NewtonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA.
Hannah I AwaiDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA.
Melissa N PaizDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA.
Jessica LamLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA.
Jonathan C HookerLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA.
Gavin HamiltonLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA.
John FontanesiCenter for Management Science in Health, Division of General Internal Medicine, Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA.
Claude B SirlinLiver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA.
University of California, San Diego · USRady Children's Hospital-San Diego · US

Funding

SAN DIEGO CLINICAL AND TRANSLATIONAL RESEARCH INSTITUTEUL1RR031980 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2010 to 2011
$14.0M
Technical Validation of MRI Biomarkers of Liver FatR01DK088925 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B., SIRLIN, CLAUDE B · 2010 to 2021
$7.1M
Development of MR Based Biomarker Panels for NAFLD _ A NASH CRN Ancillary StudyR56DK090350 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHWIMMER, JEFFREY BARNETT, SIRLIN, CLAUDE B · 2010 to 2012
$2.2M
NCRR NIH HHS UL1 RR031980NCRR NIH HHS UL1RR031980NIDDK NIH HHS DK088925-02S1NIDDK NIH HHS R01 DK088925NIDDK NIH HHS R56 DK090350NIDDK NIH HHS R56-DK090350-01A1
6 · The paper itself

Abstract

unlabelledNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. In order to advance the field of NAFLD, noninvasive imaging methods for measuring liver fat are needed. Advanced magnetic resonance imaging (MRI) has shown great promise for the quantitative assessment of hepatic steatosis but has not been validated in children. Therefore, this study was designed to evaluate the correlation and diagnostic accuracy of MRI-estimated liver proton density fat fraction (PDFF), a biomarker for hepatic steatosis, compared to histologic steatosis grade in children. The study included 174 children with a mean age of 14.0 years. Liver PDFF estimated by MRI was significantly (P < 0.01) correlated (0.725) with steatosis grade. The correlation of MRI-estimated liver PDFF and steatosis grade was influenced by both sex and fibrosis stage. The correlation was significantly (P < 0.01) stronger in girls (0.86) than in boys (0.70). The correlation was significantly (P < 0.01) weaker in children with stage 2-4 fibrosis (0.61) than children with no fibrosis (0.76) or stage 1 fibrosis (0.78). The diagnostic accuracy of commonly used threshold values to distinguish between no steatosis and mild steatosis ranged from 0.69 to 0.82. The overall accuracy of predicting the histologic steatosis grade from MRI-estimated liver PDFF was 56%. No single threshold had sufficient sensitivity and specificity to be considered diagnostic for an individual child.

conclusionsAdvanced magnitude-based MRI can be used to estimate liver PDFF in children, and those PDFF values correlate well with steatosis grade by liver histology. Thus, magnitude-based MRI has the potential for clinical utility in the evaluation of NAFLD, but at this time no single threshold value has sufficient accuracy to be considered diagnostic for an individual child.

Indexed as

Magnetic Resonance ImagingAdolescentBiomarkersCase-Control StudiesChildFemaleHumansLiverMaleNon-alcoholic Fatty Liver DiseaseProspective StudiesBiomarkers

Identifiers

PMID25529941
PMCPMC4670559
OpenAlexW1811353850

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.