Evidence map›Paper›PMID 25529848›Full record

ReviewProgress in retinal and eye research2015

The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding.

Sarah X Zhang, Jacey H Ma, Maulasri Bhatta, Steven J Fliesler, Joshua J Wang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in retinal and eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 78 citations in OpenAlex.

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  19. Emerging roles of circular RNAs in retinal diseases.Neural regeneration research · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Sarah X ZhangDepartment of Ophthalmology, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA. Electronic address: xzhang38@buffalo.edu.
Jacey H MaDepartment of Ophthalmology, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Maulasri BhattaDepartment of Ophthalmology, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA.
Steven J FlieslerDepartment of Ophthalmology, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA; SUNY Eye Institute, Buffalo, NY, USA; Research Service, Veterans Administration Western New York Healthcare System, Buffalo, NY, USA.
Joshua J WangDepartment of Ophthalmology, University at Buffalo, The State University of New York, Buffalo, NY, USA; Department of Biochemistry, University at Buffalo, The State University of New York, Buffalo, NY, USA.
University at Buffalo, State University of New York · US

Funding

ER Stress and Diabetic RetinopathyR01EY019949 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZHANG, SARAH X · 2010 to 2023
$5.5M
ISOPRENOID METABOLISM IN THE RETINAR01EY007361 · NEI · UNIVERSITY OF SOUTH FLORIDA · PI FLIESLER, STEVEN J. · 1988 to 2015
$4.4M
Study of the ER-mitochondria interface as a new target in diabetic retinopathyR21EY025061 · NEI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ZHANG, SARAH X · 2015 to 2016
$438k
NEI NIH HHS EY007361NEI NIH HHS EY019949NEI NIH HHS EY025061NEI NIH HHS R01 EY007361NEI NIH HHS R01 EY019949NEI NIH HHS R21 EY025061
6 · The paper itself

Abstract

Angiogenesis is a complex, step-wise process of new vessel formation that is involved in both normal embryonic development as well as postnatal pathological processes, such as cancer, cardiovascular disease, and diabetes. Aberrant blood vessel growth, also known as neovascularization, in the retina and the choroid is a major cause of vision loss in severe eye diseases, such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, and central and branch retinal vein occlusion. Yet, retinal neovascularization is causally and dynamically associated with vasodegeneration, ischemia, and vascular remodeling in retinal tissues. Understanding the mechanisms of retinal neovascularization is an urgent unmet need for developing new treatments for these devastating diseases. Accumulating evidence suggests a vital role for the unfolded protein response (UPR) in regulation of angiogenesis, in part through coordinating the secretion of pro-angiogenic growth factors, such as VEGF, and modulating endothelial cell survival and activity. Herein, we summarize current research in the context of endoplasmic reticulum (ER) stress and UPR signaling in retinal angiogenesis and vascular remodeling, highlighting potential implications of targeting these stress response pathways in the prevention and treatment of retinal vascular diseases that result in visual deficits and blindness.

Indexed as

AnimalsDNA-Binding ProteinsEndoplasmic Reticulum StressEye ProteinsHumansRetinal DiseasesRetinal NeovascularizationSignal TransductionUnfolded Protein ResponseDNA-Binding ProteinsEye ProteinsAngiogenesisEndoplasmic reticulum stressEndothelial cellsRetinaUnfolded protein responseVEGF

Identifiers

PMID25529848
PMCPMC4339403
OpenAlexW1979408527

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.