Evidence map›Paper›PMID 25529847›Full record

ArticleEarly intervention in psychiatry2017

Factor analysis of the Scale of Prodromal Symptoms: data from the Early Detection and Intervention for the Prevention of Psychosis Program.

Ivy F Tso, Stephan F Taylor, Tyler B Grove, Tara Niendam, Steven Adelsheim, Andrea Auther, Barbara Cornblatt, Cameron S Carter, Roderick Calkins, J Daniel Ragland and 2 more

Open access · bronzeAbstract readValidation Study
In one paragraph

Article in Early intervention in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  15. Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020
    Article
  16. Article
  17. The Critical Need for Help-Seeking Controls in Clinical High-Risk Research.Clinical psychological science : a journal of the Association for Psychological Science · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Ivy F TsoDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Stephan F TaylorDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Tyler B GroveDepartment of Psychology, University of Michigan, Ann Arbor, Michigan, USA.
Tara NiendamImaging Research Center, University of California Davis, Sacramento, California, USA.
Steven AdelsheimDepartment of Psychiatry, Stanford University, Palo Alto, California, USA.
Andrea AutherDivision of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA.
Barbara CornblattDivision of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York, USA.
Cameron S CarterImaging Research Center, University of California Davis, Sacramento, California, USA.
Roderick CalkinsMid-Valley Behavioral Care Network, Marion County Health Department, Salem, Oregon, USA.
J Daniel RaglandImaging Research Center, University of California Davis, Sacramento, California, USA.
Tamara SaleMid-Valley Behavioral Care Network, Marion County Health Department, Salem, Oregon, USA.
William R McFarlaneMaine Medical Center Research Institute, Tufts University Medical School, Portland, Maine, USA.
University of California, Davis · USUniversity of Michigan · USBehavioral Health Services · USZucker Hillside Hospital · USMaine Medical Center Research Institute · USPalo Alto University · US

Funding

4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M
CHARACTERIZATION OF PRODROMAL SCHIZOPHRENIAR01MH061523 · NIMH · LONG ISLAND JEWISH MEDICAL CENTER · PI CORNBLATT, BARBARA A. · 2000 to 2009
$3.6M
Michigan Institute for Clinical and Health Research (MCHR)TL1TR000435 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$1.8M
Michigan Institute for Clinical and Health Research (MCHR)KL2TR000434 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$1.7M
Brain mechanisms of impaired episodic memory in schizophreniaR01MH084895 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RAGLAND, JOHN D · 2010 to 2013
$1.4M
Magnetic Resonance Spectroscopy in the Psychosis Risk SyndromeR21MH101676 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAYLOR, STEPHAN F · 2013 to 2014
$428k
NCATS NIH HHS KL2 TR000434NCATS NIH HHS TL1 TR000435NIMH NIH HHS R01 MH061523NIMH NIH HHS R01 MH084895NIMH NIH HHS R21 MH101676NIMH NIH HHS U01 MH081857
6 · The paper itself

Abstract

aimThe Scale of Prodromal Symptoms (SOPS) was developed to identify individuals experiencing early signs of psychosis, a critical first step towards early intervention. Preliminary dimension reduction analyses suggested that psychosis-risk symptoms may deviate from the traditional symptom structure of schizophrenia, but findings have been inconsistent. This study investigated the phenomenology of psychosis risk symptoms in a large sample from a multi-site, national study using rigorous factor analysis procedure.

methodsParticipants were 334 help-seeking youth (age: 17.0 ± 3.3) from the Early Detection and Intervention for the Prevention of Psychosis Program, consisting of 203 participants at clinically higher risk (sum of P scores ≥ 7), 87 with clinically lower risk (sum of P scores < 7) and 44 in very early first-episode psychosis (<30 days of positive symptoms). Baseline SOPS data were subjected to principal axis factoring (PAF), estimating factors based on shared variance, with Oblimin rotation.

resultsPAF yielded four latent factors explaining 36.1% of total variance: positive symptoms; distress; negative symptoms; and deteriorated thought process. They showed reasonable internal consistency and good convergence validity, and were not orthogonal.

conclusionsThe empirical factors of the SOPS showed similarities and notable differences compared with the existing SOPS structure. Regrouping the symptoms based on the empirical symptom dimensions may improve the diagnostic validity of the SOPS. Relative prominence of the factors and symptom frequency support early identification strategies focusing on positive symptoms and distress. Future investigation of long-term functional implications of these symptom factors may further inform intervention strategies.

Indexed as

Early DiagnosisEarly Medical InterventionProdromal SymptomsAdolescentFemaleHumansMalePatient Acceptance of Health CarePsychiatric Status Rating ScalesPsychometricsPsychotic DisordersReproducibility of ResultsYoung Adultfactor analysisprodromepsychosisschizophreniaultra high risk

Identifiers

PMID25529847
PMCPMC4723283
OpenAlexW2162829421

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.