Evidence map›Paper›PMID 25529612›Full record

ReviewCell biochemistry and function2015

The role of nuclear hormone receptors in cutaneous wound repair.

Sandra Rieger, Hengguang Zhao, Paige Martin, Koichiro Abe, Thomas S Lisse

Open access · greenAbstract readReview
In one paragraph

Review in Cell biochemistry and function, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 90 citations in OpenAlex.

  1. The Effects and Molecular Mechanisms of a Peptide fromMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Comparison of the effects ofVeterinarni medicina · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Vascularization strategies in tissue engineering approaches for soft tissue repair.Journal of tissue engineering and regenerative medicine · 2021
    Review
  10. Article
  11. Article
  12. Wound Healing Effect of Nonthermal Atmospheric Pressure Plasma Jet on a Rat Burn Wound Model: A Preliminary Study.Journal of burn care & research : official publication of the American Burn Association · 2019
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Sandra RiegerCenter for Regenerative Biology and Medicine, MDI Biological Laboratory, Salisbury Cove, ME, USA.
Hengguang Zhao
Paige Martin
Koichiro Abe
Thomas S Lisse
Mount Desert Island Biological Laboratory · USCenter for Neuroscience and Regenerative Medicine · USChongqing Medical University · CNTokai University · JP

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
NIGMS NIH HHS 1P20GM104318NIGMS NIH HHS P20GM0103423NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

The cutaneous wound repair process involves balancing a dynamic series of events ranging from inflammation, oxidative stress, cell migration, proliferation, survival and differentiation. A complex series of secreted trophic factors, cytokines, surface and intracellular proteins are expressed in a temporospatial manner to restore skin integrity after wounding. Impaired initiation, maintenance or termination of the tissue repair processes can lead to perturbed healing, necrosis, fibrosis or even cancer. Nuclear hormone receptors (NHRs) in the cutaneous environment regulate tissue repair processes such as fibroplasia and angiogenesis. Defects in functional NHRs and their ligands are associated with the clinical phenotypes of chronic non-healing wounds and skin endocrine disorders. The functional relationship between NHRs and skin niche cells such as epidermal keratinocytes and dermal fibroblasts is pivotal for successful wound closure and permanent repair. The aim of this review is to delineate the cutaneous effects and cross-talk of various nuclear receptors upon injury towards functional tissue restoration.

Indexed as

Skin Physiological PhenomenaWound HealingAnimalsHumansReceptors, Cytoplasmic and NuclearSkinReceptors, Cytoplasmic and Nuclearhormonesinnervationkeratinocytesnuclear receptorsregenerationtissue repairvitamin Dwound healing

Identifiers

PMID25529612
PMCPMC4357276
OpenAlexW1532323817

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.