Evidence map›Paper›PMID 25529538›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Single-molecule bioelectronics.

Jacob K Rosenstein, Serge G Lemay, Kenneth L Shepard

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jacob K RosensteinSchool of Engineering, Brown University, Providence, RI, USA.
Serge G LemayMESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.
Kenneth L ShepardDepartments of Electrical and Biomedical Engineering, Columbia University, New York, NY, USA.

Funding

Translational CoreU19AI109761 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARIC, RALPH S · 2014 to 2018
$32.6M
Single Molecule Real Time Electronic SequencingR01HG006882 · NHGRI · INTEL LABS · PI LEMAY, SERGE GUY, SHEPARD, KENNETH L · 2012 to 2015
$5.0M
Studies of Riboswitch-Mediated Transcriptional Control Using Single-Molecule FielR01GM107417 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L, NUCKOLLS, COLIN P · 2014 to 2017
$1.5M
Integrated, multiplexed high-frequency electronic analysis of DNA in nanoporesR01HG006879 · NHGRI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEPARD, KENNETH L · 2012 to 2014
$1.4M
NHGRI NIH HHS R01 HG006879NHGRI NIH HHS R01-HG006879NHGRI NIH HHS R01 HG006882NHGRI NIH HHS R01-HG006882NIAID NIH HHS U19 AI109761NIAID NIH HHS U19-AI109761NIGMS NIH HHS R01 GM107417NIGMS NIH HHS R01-GM107417
6 · The paper itself

Abstract

Experimental techniques that interface single biomolecules directly with microelectronic systems are increasingly being used in a wide range of powerful applications, from fundamental studies of biomolecules to ultra-sensitive assays. In this study, we review several technologies that can perform electronic measurements of single molecules in solution: ion channels, nanopore sensors, carbon nanotube field-effect transistors, electron tunneling gaps, and redox cycling. We discuss the shared features among these techniques that enable them to resolve individual molecules, and discuss their limitations. Recordings from each of these methods all rely on similar electronic instrumentation, and we discuss the relevant circuit implementations and potential for scaling these single-molecule bioelectronic interfaces to high-throughput arrayed sensing platforms.

Indexed as

ElectronicsAmplifiers, ElectronicCatalysisIon ChannelsNanowiresOxidation-ReductionIon Channels

Identifiers

PMID25529538
PMCPMC4476964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.