Evidence map›Paper›PMID 25529351›Full record

Trial reportCritical care (London, England)2014

High-flow nasal cannula oxygen versus non-invasive ventilation in patients with acute hypoxaemic respiratory failure undergoing flexible bronchoscopy--a prospective randomised trial.

Marcel Simon, Stephan Braune, Daniel Frings, Ann-Kathrin Wiontzek, Hans Klose, Stefan Kluge

5 registry-linked trialsOpen access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01870765 nacompletednot on this map

Prospective Randomised Study on the Safety of Non-invasive Ventilation Versus High-flow Oxygen in Patients With Hypoxemic Respiratory Failure Undergoing Fiberoptic Bronchoscopy.

TypeinterventionalSponsorUniversitätsklinikum Hamburg-EppendorfRan2013 to 2014Enrolled40ConditionsRespiratory FailureArmsnon-invasive ventilation, high-flow oxygen, fiberoptic bronchoscopy
NCT02523573 completednot on this map

High Flow Nasal Oxygen for Bronchoscopy With Bronchoalveolar Lavage in Acute Respiratory Failure Patients: the OptiBAL Study.

TypeobservationalSponsorHôpital Louis MourierRan2011 to 2015Enrolled30ConditionsRespiratory InsufficiencyArmsAdult ARF ICU patients needing BAL with HFNC
NCT03009877 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Preoxygenation With Optiflow™, a High Flow Nasal Cannula (HFNC), is Superior to Preoxygenation With Facemask in Morbidly Obese Patients Undergoing General Anesthesia

TypeinterventionalSponsorMontefiore Medical CenterRan2018 to 2019Enrolled0ConditionsObesity, MorbidArmsOptiflow F&P 850™ System, facemask, Rocuronium, Propofol, Fentanyl
NCT03168815 naactive not recruitingnot on this mapstarted 2018, after this paper: background citation

Low-Flow vs. High-Flow Nasal Cannula for Hypoxemic Immunocompromised Patients During Diagnostic Bronchoscopy: A Randomized Controlled Trial

TypeinterventionalSponsorMount Sinai Hospital, CanadaRan2018 to 2025Enrolled98ConditionsImmunocompromised, Hematologic Malignancy, Post Hematopoietic Stem Cell Transplant, HypoxiaArmsHigh Flow Nasal Cannula or Low Flow Nasal Cannula
NCT05759832 nacompletednot on this mapstarted 2023, after this paper: background citation

Modified Nasal High-flow Oxygen Therapy for Acute Respiratory Failure Patients Undergoing Flexible Bronchoscopy

TypeinterventionalSponsorBeijing Chao Yang HospitalRan2023 to 2025Enrolled160ConditionsAcute Hypoxemic Respiratory Failure, High-flow Nasal Cannula OxygenArmsModified HFNC oxygen therapy, Non-rebreathing reservoir mask
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it, 148 citations in OpenAlex.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marcel SimonDepartment of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. m.simon@uke.de.
Stephan BrauneDepartment of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. sbraune@uke.de.
Daniel FringsDepartment of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. d.frings@uke.de.
Ann-Kathrin WiontzekDepartment of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. ak_wiontzek@freenet.de.
Hans KloseDepartment of Respiratory Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. klose@uke.de.
Stefan KlugeDepartment of Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. s.kluge@uke.de.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCritically ill patients with respiratory failure undergoing bronchoscopy have an increased risk of hypoxaemia-related complications. Previous studies have shown that in awake, hypoxaemic patients non-invasive ventilation (NIV) is helpful in preventing gas exchange deterioration during bronchoscopy. An alternative and increasingly used means of oxygen delivery is its application via high-flow nasal cannula (HFNC). This study was conducted to compare HFNC with NIV in patients with acute hypoxaemic respiratory failure undergoing flexible bronchoscopy.

methodsProspective randomised trial randomising 40 critically ill patients with hypoxaemic respiratory failure to receive either NIV or HFNC during bronchoscopy in the intensive care unit.

resultsAfter the initiation of NIV and HFNC, oxygen levels were significantly higher in the NIV group compared to the HFNC group. Two patients were unable to proceed to bronchoscopy after the institution of HFNC due to progressive hypoxaemia. During bronchoscopy, one patient on HFNC deteriorated due to intravenous sedation requiring non-invasive ventilatory support. Bronchoscopy was well tolerated in all other patients. There were no significant differences between the two groups regarding heart rate, mean arterial pressure and respiratory rate. Three patients in the NIV group and one patient in the HFNC group were intubated within 24 hours after the end of bronchoscopy (P = 0.29).

conclusionsThe application of NIV was superior to HFNC with regard to oxygenation before, during and after bronchoscopy in patients with moderate to severe hypoxaemia. In patients with stable oxygenation under HFNC, subsequent bronchoscopy was well tolerated.

trial registrationClinicalTrials.gov NCT01870765. Registered 30 May 2013.

Indexed as

Nasal CavityAcute DiseaseAgedBronchoscopyFemaleHumansHypoxiaMaleMiddle AgedNoninvasive VentilationOxygen Inhalation TherapyPliabilityProspective StudiesRespiratory Insufficiency

Identifiers

PMID25529351
PMCPMC4300050
OpenAlexW2111669778

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.