Evidence map›Paper›PMID 25529062›Full record

ArticleNutrients2014

Distribution and determinants of plasma homocysteine levels in rural Chinese twins across the lifespan.

Yuelong Ji, Xiangyi Kong, Guoying Wang, Xiumei Hong, Xin Xu, Zhu Chen, Tami Bartell, Xiping Xu, Genfu Tang, Fanfan Hou and 3 more

Open access · goldAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 2 countries.

Yuelong JiCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E4132 Baltimore, MD 21205-2179, USA. yji7@jhu.edu.
Xiangyi KongAnzen Hospital, Beijing Capital Medical University, Beijing 100069, China. sherrykxy@gmail.com.
Guoying WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E4132 Baltimore, MD 21205-2179, USA. gwang24@jhu.edu.
Xiumei HongCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E4132 Baltimore, MD 21205-2179, USA. xhong3@jhu.edu.
Xin XuInstitute of Biomedicine, Anhui Medical University, Hefei 230032, China. ffhouguangzhou@163.com.
Zhu ChenCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E4132 Baltimore, MD 21205-2179, USA. zchen31@jhu.edu.
Tami BartellMary Ann & J. Milburn Smith Child Health Research Program, Stanley Manne Children's Research Institute, Chicago, IL 60614, USA. TBartell@luriechildrens.org.
Xiping XuInstitute of Biomedicine, Anhui Medical University, Hefei 230032, China. ffhouguangzhou@163.com.
Genfu TangSchool of Health Administration, Anhui Medical University, Hefei 230032, China. tanggenfu@163.com.
Fanfan HouNational Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. ffhouguangzhou@163.com.
Yong HuoDepartment of Cardiology, Peking University First Hospital, Beijing 100034, China. huoyong@263.net.cn.
Xiaobin WangCenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, E4132 Baltimore, MD 21205-2179, USA. xwang82@jhu.edu.
Binyan WangNational Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. binyanwang126@126.com.
Johns Hopkins University · USNanfang Hospital · CNAnhui Medical University · CNCapital Medical University · CNJohns Hopkins Medicine · USLurie Children's Hospital · USPeking University First Hospital · CNSouthern Medical University · CN

Funding

Epidemiology of the Metabolic Syndrome in ChildrenR01HD049059 · NICHD · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI WANG, XIAOBIN · 2005 to 2009
$2.1M
Sleep and Adiposity: A Prospective Twin StudyR01HL086461 · NHLBI · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI LIU, XIN · 2006 to 2009
$2.0M
Establishing the Precursors of Osteoporosis in ChildrenR01AG032227 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, XIPING · 2007 to 2010
$1.3M
NHLBI NIH HHS R01 HL086461NIA NIH HHS R01 AG032227NICHD NIH HHS R01 HD049059
6 · The paper itself

Abstract

Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10-66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

Indexed as

LongevityAdolescentAdultAgedAge FactorsAsian PeopleCardiovascular DiseasesChildChinaFemaleGenetic Predisposition to DiseaseGenetic VariationGenotypeHomocysteineHumansLinear ModelsHomocysteineMethylenetetrahydrofolate Reductase (NADPH2)MTHFR protein, human

Identifiers

PMID25529062
PMCPMC4277006
OpenAlexW2155360942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.