Evidence map›Paper›PMID 25528994›Full record

ReviewTrends in cardiovascular medicine2015

Kruppel-like factors in muscle health and disease.

Domenick A Prosdocimo, M Khaled Sabeh, Mukesh K Jain

Open access · greenAbstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Effect ofInternational journal of molecular sciences · 2025
    Review
  7. KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle atrophy.Journal of cachexia, sarcopenia and muscle · 2024
    Article
  8. Molecular mechanisms underlying sarcopenia in heart failure.The journal of cardiovascular aging · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. KLF9 deficiency protects the heart from inflammatory injury triggered by myocardial infarction.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Identification of a KLF5-dependent program and drug development for skeletal muscle atrophy.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Domenick A ProsdocimoCase Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
M Khaled SabehCase Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH.
Mukesh K JainCase Cardiovascular Research Institute, Cleveland, OH; Harrington Heart & Vascular Institute, Cleveland, OH; Department of Medicine, University Hospitals Case Medical Center, Cleveland, OH; Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, OH. Electronic address: mukesh.jain2@case.edu.
University Hospitals Case Medical Center · USCase Western Reserve University · US

Funding

KLF2, monocyte activation and vascular inflammationR01HL086548 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2007 to 2016
$3.5M
KLF15 in vascular diseaseR01HL112486 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2012 to 2015
$1.9M
Transcriptional control of endothelium in APS by Kruppel Like factorsR01HL123098 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI JAIN, MUKESH KUMAR, MCCRAE, KEITH R. · 2014 to 2017
$1.8M
KLF4 , the endothelium, and vascular inflammationR01HL097593 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2010 to 2013
$1.5M
KLF4 and Myeloid Cell BiologyR01HL110630 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2011 to 2014
$1.5M
KLF15 in Cardiac MetabolismR01HL119195 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2014 to 2017
$1.2M
NHLBI NIH HHS R01 HL086548NHLBI NIH HHS R01 HL097593NHLBI NIH HHS R01 HL110630NHLBI NIH HHS R01 HL112486NHLBI NIH HHS R01 HL119195NHLBI NIH HHS R01 HL123098
6 · The paper itself

Abstract

Kruppel-like factors (KLF) are zinc-finger DNA-binding transcription factors that are critical regulators of tissue homeostasis. Emerging evidence suggests that KLFs are critical regulators of muscle biology in the context of cardiovascular health and disease. The focus of this review is to provide an overview of the current state of knowledge regarding the physiologic and pathologic roles of KLFs in the three lineages of muscle: cardiac, smooth, and skeletal.

Indexed as

HomeostasisCardiovascular DiseasesHumansKruppel-Like Transcription FactorsMuscle, SkeletalMuscle, SmoothMyocardiumUp-RegulationKruppel-Like Transcription Factors

Identifiers

PMID25528994
PMCPMC4422160
OpenAlexW1981790371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.