ArticleOncotarget2014
Higher mortality and impaired elimination of bacteria in aged mice after intracerebral infection with E. coli are associated with an age-related decline of microglia and macrophage functions.
Article in Oncotarget, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Glatiramer acetate stimulates phagocytosis and intracellular killing ofFrontiers in immunology · 2026Article
- Gum Arabic Increases Phagocytosis ofAntibiotics (Basel, Switzerland) · 2024Article
- Nanotubes from bacteriophage tail sheath proteins: internalisation by cancer cells and macrophages.Nanoscale advances · 2023Article
- Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155.Immunity & ageing : I & A · 2022Article
- Intracerebral Infection withJournal of Alzheimer's disease reports · 2022Article
- Interferon-gamma impairs phagocytosis ofCytokine: X · 2021Article
- Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Aged mice show an increased mortality after anesthesia with a standard dose of ketamine/xylazine.Laboratory animal research · 2019Article
- Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.Journal of neuroinflammation · 2018Article
- Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte.BMC geriatrics · 2018Article
- Prophylactic Palmitoylethanolamide Prolongs Survival and Decreases Detrimental Inflammation in Aged Mice With Bacterial Meningitis.Frontiers in immunology · 2018Article
- Age does not influence the disease course in a mouse model ofImmunity & ageing : I & A · 2018Article
- Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect.Ageing research reviews · 2017Review
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10 authors.
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Abstract
Incidence and mortality of bacterial meningitis are strongly increased in aged compared to younger adults demanding new strategies to improve prevention and therapy of bacterial central nervous system (CNS) infections the elderly. Here, we established a geriatric mouse model for an intracerebral E. coli infection which reflects the clinical situation in aged patients: After intracerebral challenge with E. coli K1, aged mice showed a higher mortality, a faster development of clinical symptoms, and a more pronounced weight loss. Elimination of bacteria and systemic inflammatory response were impaired in aged mice, however, the number of infiltrating leukocytes and microglial cells in the CNS of aged and young mice did not differ substantially. In vitro, primary microglial cells and peritoneal macrophages from aged mice phagocytosed less E. coli and released less NO and cyto-/chemokines compared to cells from young mice both without activation and after stimulation by agonists of TLR 2, 4, and 9. Our results suggest that the age-related decline of microglia and macrophage functions plays an essential role for the higher susceptibility of aged mice to intracerebral infections. Strategies to improve the phagocytic potential of aged microglial cells and macrophages appear promising for prevention and treatment of CNS infections in elderly patients.
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