Evidence map›Paper›PMID 25528587›Full record

ArticleBiochemical and biophysical research communications2015

Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy.

Estibaliz Castillero, Hirokazu Akashi, Catherine Wang, Marc Najjar, Ruiping Ji, Peter J Kennel, H Lee Sweeney, Paul C Schulze, Isaac George

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 50 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Myostatin and the Heart.Biomolecules · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Steps toward therapeutically targeting the activin type II receptor for treating heart failure.American journal of physiology. Heart and circulatory physiology · 2020
    Article
  17. Article
  18. Article
  19. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.Molecular therapy : the journal of the American Society of Gene Therapy · 2019
    Article
  20. The Role of the TGF-β Superfamily in Myocardial Infarction.Frontiers in cardiovascular medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Estibaliz CastilleroDivision of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
Hirokazu AkashiDepartment of Cardiovascular Surgery, Juntendo University, Tokyo, Japan.
Catherine WangDivision of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
Marc NajjarDivision of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
Ruiping JiDivision of Cardiology, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
Peter J KennelDivision of Cardiology, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
H Lee SweeneyDepartment of Physiology, University of Pennsylvania, Philadelphia, PA, United States.
Paul C SchulzeDivision of Cardiology, College of Physicians and Surgeons of Columbia University, New York, NY, United States.
Isaac GeorgeDivision of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University, New York, NY, United States. Electronic address: Ig2006@cumc.coumbia.edu.
Columbia University · USJuntendo University · JPUniversity of Pennsylvania · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Cardiac Lipotoxicity and Ceramide Metabolism in Heart FailureR01HL114813 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLOMBO, PAOLO C, SCHULZE, P. CHRISTIAN · 2013 to 2017
$3.0M
NCATS NIH HHS UL1 TR000040NCRR NIH HHS RR024156NCRR NIH HHS UL1 RR024156NHLBI NIH HHS R01 HL114813
6 · The paper itself

Abstract

unlabelledMyostatin (MSTN), a negative regulator of muscle growth and size, is increased after acute myocardial infarction (AMI) but timing of upregulation after injury is not known. In this study, we investigated the timing of the MSTN/AKT/p38 pathway activation in heart and skeletal muscle after AMI, as well as the potential effect of cardiac injury-related MSTN endocrine signaling on skeletal muscle and other circulating growth factors.

methodsCoronary artery ligation was performed in C57BL/6 mice at age 8 weeks to induce AMI. Mice were sacrificed at different time points (10 m, 1 h, 2 h, 6 h, 12 h, 24 h, 1 week, 2 weeks, 1 months and 2 months) after surgery (n=3 per time point, n=18 total).

resultsCardiac and circulating MSTN upregulation occurred as early as 10 min after AMI. Two months after AMI, increased cardiac MSTN/SMAD2,3 and p38 together with decreased IGF-1/AKT signaling suggest an anti-hypertrophic profile. In skeletal muscle, an absence of local MSTN increase was accompanied by increased MSTN-dependent SMAD2,3 signaling, suggestive of paracrine effects due to cardiac-derived MSTN. Protein degradation by the ubiquitin-proteasome system in the skeletal muscle was also evident. Serum from 24h post-MI mice effectively induced a MSTN-dependent increase in atrogin1 and MuRF1.

conclusionOur study shows that cardiac MTSN activation occurs rapidly after cardiac ischemia and may be involved in peripheral protein degradation in the skeletal muscle by activating atrogin1 and MuRF1.

Indexed as

Up-RegulationAnimalsBiomarkersMaleMice, Inbred C57BLMuscle ProteinsMuscle, SkeletalMuscular AtrophyMyocardial IschemiaMyocardiumMyostatinSignal TransductionSKP Cullin F-Box Protein LigasesSmad ProteinsTime FactorsTripartite Motif ProteinsBiomarkersFbxo32 protein, mouseMstn protein, mouseMuscle ProteinsMyostatinSKP Cullin F-Box Protein LigasesSmad ProteinsTrim63 protein, mouseTripartite Motif ProteinsUbiquitin-Protein LigasesCardiac cachexiaGrow factorsHeart failureIschemiaMyostatin

Identifiers

PMID25528587
PMCPMC4967536
OpenAlexW2055891387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.