Evidence map›Paper›PMID 25528432›Full record

Trial reportAtherosclerosis2015

High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans.

Peter J H Jones, Dylan S MacKay, Vijitha K Senanayake, Shuaihua Pu, David J A Jenkins, Philip W Connelly, Benoît Lamarche, Patrick Couture, Penny M Kris-Etherton, Sheila G West and 4 more

Open access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. A role for proteoglycans in vascular disease.Matrix biology : journal of the International Society for Matrix Biology · 2018
    Review
  15. Article
  16. Article
  17. Review
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Peter J H JonesRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Peter.Jones@umanitoba.ca.
Dylan S MacKayRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
Vijitha K SenanayakeRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
Shuaihua PuRichardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB, Canada.
David J A JenkinsSt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Philip W ConnellySt. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Benoît LamarcheInstitute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada.
Patrick CoutureInstitute of Nutrition and Functional Foods, Laval University, Quebec City, QC, Canada.
Penny M Kris-EthertonDepartment of Nutritional Sciences, Pennsylvania State University, PA, USA.
Sheila G WestDepartment of Nutritional Sciences, Pennsylvania State University, PA, USA; Department of Biobehavioral Health, Pennsylvania State University, PA, USA.
Xiaoran LiuDepartment of Nutritional Sciences, Pennsylvania State University, PA, USA.
Jennifer A FlemingDepartment of Nutritional Sciences, Pennsylvania State University, PA, USA.
Roy R HantganDepartment of Biochemistry Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Lawrence L RudelDepartment of Biochemistry Wake Forest University School of Medicine, Winston-Salem, NC, USA; Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Pennsylvania State University · USUniversity of Manitoba · CASt. Michael's Hospital · CAUniversité Laval · CAWake Forest University · US

Funding

TISSUE CULTURE COREP01HL049373 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RUDEL, LAWRENCE L · 1993 to 2012
$23.8M
Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
NCATS NIH HHS UL1 TR000127NCATS NIH HHS UL1TR000127NHLBI NIH HHS HL 49373NHLBI NIH HHS P01 HL049373
6 · The paper itself

Abstract

Oleic acid consumption is considered cardio-protective according to studies conducted examining effects of the Mediterranean diet. However, animal models have shown that oleic acid consumption increases LDL particle cholesteryl oleate content which is associated with increased LDL-proteoglycan binding and atherosclerosis. The objective was to examine effects of varying oleic, linoleic and docosahexaenoic acid consumption on human LDL-proteoglycan binding in a non-random subset of the Canola Oil Multi-center Intervention Trial (COMIT) participants. COMIT employed a randomized, double-blind, five-period, cross-over trial design. Three of the treatment oil diets: 1) a blend of corn/safflower oil (25:75); 2) high oleic canola oil; and 3) DHA-enriched high oleic canola oil were selected for analysis of LDL-proteoglycan binding in 50 participants exhibiting good compliance. LDL particles were isolated from frozen plasma by gel filtration chromatography and LDL cholesteryl esters quantified by mass-spectrometry. LDL-proteoglycan binding was assessed using surface plasmon resonance. LDL particle cholesterol ester fatty acid composition was sensitive to the treatment fatty acid compositions, with the main fatty acids in the treatments increasing in the LDL cholesterol esters. The corn/safflower oil and high-oleic canola oil diets lowered LDL-proteoglycan binding relative to their baseline values (p = 0.0005 and p = 0.0012, respectively). At endpoint, high-oleic canola oil feeding resulted in lower LDL-proteoglycan binding than corn/safflower oil (p = 0.0243) and DHA-enriched high oleic canola oil (p = 0.0249), although high-oleic canola oil had the lowest binding at baseline (p = 0.0344). Our findings suggest that high-oleic canola oil consumption in humans increases cholesteryl oleate percentage in LDL, but in a manner not associated with a rise in LDL-proteoglycan binding.

Indexed as

Diet, MediterraneanAdultCanadaCardiovascular DiseasesCholesterol EstersCholesterol, LDLCorn OilCross-Over StudiesDietary FatsDocosahexaenoic AcidsDouble-Blind MethodFatty Acids, MonounsaturatedFemaleHumansLinoleic AcidMaleCholesterol EstersCholesterol, LDLcholesteryl oleateCorn OilDietary FatsDocosahexaenoic AcidsFatty Acids, MonounsaturatedLinoleic AcidOleic AcidProteoglycansRapeseed OilSafflower OilCholesterolFatty acidsLDLNutritionOleic acidProteoglycan

Identifiers

PMID25528432
PMCPMC4346138
OpenAlexW2162228990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.