ArticleInternational journal of cardiology2015
The impact of gender and left atrial blood stasis on adiponectin levels in non-valvular atrial fibrillation.
Article in International journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Left atrial appendage blood flow analysis using four-dimensional flow magnetic resonance imaging.General thoracic and cardiovascular surgery · 2026Article
- Potential involvement of adiponectin in obesity-associated erosive esophagitis.Journal of clinical biochemistry and nutrition · 2020Article
- Evaluation of Atrial Electromechanical Delay in Children with Obesity.Medicina (Kaunas, Lithuania) · 2019Article
- Left atrial appendage occlusion: A better alternative to anticoagulation?World journal of cardiology · 2017Review
- Relationship between body mass index and left atrial appendage thrombus in nonvalvular atrial fibrillation.Journal of thrombosis and thrombolysis · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundObesity is a risk factor for non-valvular atrial fibrillation (NVAF), diabetes mellitus, and hypertension. Adiponectin, a unique biomarker of adipose tissue, has antiinflammatory, insulin-sensitizing, and antiatherogenic properties and is known to be higher in women. The relationship between adiponectin, gender, and thromboembolic risk in atrial fibrillation however is unknown.
methodsThe relationship between gender, adiponectin levels, and echocardiographic measures of blood stagnation and left atrial appendage thrombus (LAAT) was assessed in 209 patients with NVAF (55 women and 154 men; mean age 63 ± 14 years) compared to 70 normal sinus rhythm controls (29 women and 41 men; mean age 64 ± 14 years). Total adiponectin was measured by solid-phase ELISA. Demographic and clinical variables of CHADS2 and CHA2DS2-VASc were collected, and spontaneous echocardiographic contrast (SEC), left atrial appendage emptying velocity (LAAEV) and left atrium volume index (LAVI) were measured prospectively.
resultsElevated adiponectin was associated with advanced cardiovascular pathology and permanent arrhythmia but only in men with NVAF. In NVAF men, a step-wise increase in adiponectin levels was noted relative to increasing intensity of SEC and decreasing LAAEV. Adiponectin level >16657 ng/ml predicted LAAT (OR: 3.66; 95% Cl: 1.21-11.48; p=0.022) after adjustment for CHADS2 score in men but not in women with NVAF.
conclusionsThere is a direct correlation between elevated adiponectin level and the degree of left atrial blood stasis in men but not in women with NVAF. High adiponectin levels can be used as an important variable in the prediction of LAAT.
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Registered trials
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