Evidence map›Paper›PMID 25528251›Full record

Trial reportOral and maxillofacial surgery2015

Postoperative hemostatic efficacy of gauze soaked in tranexamic acid, fibrin sponge, and dry gauze compression following dental extractions in anticoagulated patients with cardiovascular disease: a prospective, randomized study.

Eduardo Costa Studart Soares, Fábio Wildson Gurgel Costa, Tácio Pinheiro Bezerra, Carlos Bruno Pinheiro Nogueira, Paulo Goberlânio de Barros Silva, Saulo Hilton Botelho Batista, Fabrício Bitu Sousa, Cristiane Sá Roriz Fonteles

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Oral and maxillofacial surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04846114 (Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin), which is not on this map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04846114 nacompletednot on this mapstarted 2016, after this paper: background citation

Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study

TypeinterventionalSponsorJorge Ernesto AguilarRan2016 to 2019Enrolled71ConditionsOral Anticoagulant TherapyArmsDental implant surgery
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eduardo Costa Studart SoaresDivision of Oral and Maxillofacial Surgery, Department of Clinical Dentistry, School of Dentistry, Federal University of Ceará, Rua Cap. Francisco Pedro S/N, Rodolfo Teófilo, Fortaleza, CE, 60430-170, Brazil.
Fábio Wildson Gurgel Costa
Tácio Pinheiro Bezerra
Carlos Bruno Pinheiro Nogueira
Paulo Goberlânio de Barros Silva
Saulo Hilton Botelho Batista
Fabrício Bitu Sousa
Cristiane Sá Roriz Fonteles
Universidade Federal do Ceará · BRHospital Universitário Walter Cantídio · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral anticoagulants are widely prescribed drugs. Interruption of anticoagulant therapy prior to oral surgery has been an issue of great controversy. The purpose of this study was to evaluate the incidence of bleeding complications after dental extractions in patients on anticoagulant therapy (warfarin) in whom different local hemostatic methods were used. MATERIAL AND

methodsPatients using warfarin and requiring extractions of at least two teeth were screened to participate in this prospective, randomized study. Extraction sites were considered as sampling units (statistically representative sample size) and were allocated to one of the three study groups (G1-4.8% tranexamic acid; G2-fibrin sponge; and G3-no local hemostatic agents).

resultsEighty-four extraction sites were obtained from patients with mitral valve prolapse (47.4%), prosthetic cardiac valve (23.7%), venous thromboembolism (21.1%), and pulmonary embolism (5.2%). International normalized ratio (INR) values ranged between 2.1 and 3.1 (mean 2.51 ± 0.1). Postoperative bleeding was observed in four surgical sites (p < 0.001) and was mainly in older patients (p = 0.005). DISCUSSION: The three local hemostatic protocols were similarly effective in controlling postoperative bleeding in patients undergoing anticoagulant therapy with warfarin. The majority of teeth could be extracted with minimal problems in patients with cardiovascular diseases receiving treatment with anticoagulant therapy.

Indexed as

Surgical SpongesTooth ExtractionAdministration, TopicalAdultAgedAnticoagulantsBrazilCardiovascular DiseasesFemaleFibrin Tissue AdhesiveHemostatic TechniquesHumansMaleMiddle AgedPostoperative HemorrhagePressureAnticoagulantsFibrin Tissue AdhesiveTranexamic AcidWarfarin

Identifiers

PMID25528251
OpenAlexW2083395507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.