Evidence map›Paper›PMID 25527774›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2015

Menstrual cycle and sex effects on sympathetic responses to acute chemoreflex stress.

Charlotte W Usselman, Tamara I Gimon, Chantelle A Nielson, Torri A Luchyshyn, Nicole S Coverdale, Stan H M Van Uum, J Kevin Shoemaker

2 registry-linked trialsOpen access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05001048 nacompletednot on this mapstarted 2019, after this paper: background citation

Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.

TypeinterventionalSponsorUniversity of AlbertaRan2019 to 2022Enrolled14ConditionsVasodilation, VasoconstrictionArmsPhenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia, Hyperoxia
NCT05525416 nacompletednot on this mapstarted 2022, after this paper: background citation

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

TypeinterventionalSponsorUniversity of AlbertaRan2022 to 2023Enrolled17ConditionsVasodilation, VasoconstrictionArmsSodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine, Isometric Handgrip and Post-Exercise Circulatory Occlusion, Rhythmic Handgrip
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 56 citations in OpenAlex.

  1. Trial
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  5. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  6. Article
  7. Article
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  9. Article
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  11. Article
  12. Review
  13. Article
  14. Baroreflex responses to limb venous distension in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  15. Article
  16. Article
  17. Integrative cardiovascular control in women: Regulation of blood pressure, body temperature, and cerebrovascular responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Review
  18. Sex differences in vascular transduction of sympathetic nerve activity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2020
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charlotte W UsselmanNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada;
Tamara I GimonNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada;
Chantelle A NielsonNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada;
Torri A LuchyshynNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada;
Nicole S CoverdaleNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada;
Stan H M Van UumDepartment of Medicine, Western University, London, Ontario, Canada; Lawson Health Research Institute, Western University, London, Ontario, Canada; and.
J Kevin ShoemakerNeurovascular Research Laboratory, School of Kinesiology, Western University, London, Ontario, Canada; Department of Physiology and Pharmacology, Western University, London, Ontario, Canada kshoemak@uwo.ca.
Western University · CALawson Health Research Institute · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

This study aimed to examine the effects of sex (males vs. females) and sex hormones (menstrual cycle phases in women) on sympathetic responsiveness to severe chemoreflex activation in young, healthy individuals. Muscle sympathetic nerve activity (MSNA) was measured at baseline and during rebreathing followed by a maximal end-inspiratory apnea. In women, baseline MSNA was greater in the midluteal (ML) than early-follicular (EF) phase of the menstrual cycle. Baseline MSNA burst incidence was greater in men than women, while burst frequency and total MSNA were similar between men and women only in the ML phase. Chemoreflex activation evoked graded increases in MSNA burst frequency, amplitude, and total activity in all participants. In women, this sympathoexcitation was greater in the EF than ML phase. The sympathoexcitatory response to chemoreflex stimulation of the EF phase in women was also greater than in men. Nonetheless, changes in total peripheral resistance were similar between sexes and menstrual cycle phases. This indicates that neurovascular transduction was attenuated during the EF phase during chemoreflex activation, thereby offsetting the exaggerated sympathoexcitation. Chemoreflex-induced increases in mean arterial pressure were similar across sexes and menstrual cycle phases. During acute chemoreflex stimulation, reduced neurovascular transduction could provide a mechanism by which apnea-associated morbidity might be attenuated in women relative to men.

Indexed as

ReflexStress, PhysiologicalAction PotentialsAdultBiomarkersChemoreceptor CellsFemaleHemodynamicsHumansHypercapniaHypoxiaMaleMenstrual CycleMuscle, SkeletalSex FactorsSympathetic Nervous SystemBiomarkershypercapniahypoxiamenstrual cyclemuscle sympathetic nerve activitysex differences

Identifiers

PMID25527774
PMCPMC4360053
OpenAlexW2007917266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.