SynthesisThe American journal of clinical nutrition2015
Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
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7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Vitamin C Urinary Loss in Fabry Disease: Clinical and Genomic Characteristics of Vitamin C Renal Leak.The Journal of nutrition · 2023Article
- Vexed causal inferences in nutritional epidemiology-call for genetic help.International journal of epidemiology · 2022Article
- Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination.Nutrients · 2021Review
- Whole Genome Interpretation for a Family of Five.Frontiers in genetics · 2021Article
- Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies.Antioxidants (Basel, Switzerland) · 2020Review
- Genetic variants in a sodium-dependent vitamin C transporter gene and age-related cataract.The British journal of ophthalmology · 2019Article
- Vitamin C: the known and the unknown and Goldilocks.Oral diseases · 2016Review
Corrections and comments
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Authors and funding
19 authors at 1 institution in 2 countries.
Kaitlin H WadeFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Nita G ForouhiFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Derek G CookFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Paul JohnsonFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Alex McConnachieFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Richard W MorrisFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Santiago RodriguezFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Zheng YeFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Shah EbrahimFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Sandosh PadmanabhanFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Graham WattFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
K Richard BruckdorferFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Nick J WarehamFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Peter H WhincupFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Stephen ChanockFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Naveed SattarFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Debbie A LawlorFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
George Davey SmithFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
Nicholas J TimpsonFrom the Medical Research Council (MRC) Integrative Epidemiology Unit (KHW, DAL, GDS, and NJT) and the School of Social and Community Medicine (KHW, NGF, SR, DAL, GDS, and NJT), University of Bristol, Bristol, United Kingdom; the MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, United Kingdom (NGF, ZY, and NJW); the Division of Community and Health Sciences, St. George's University of London, London, United Kingdom (DGC and PHW); the Robertson Centre for Biostatistics, Glasgow, United Kingdom (PJ and AM); the Department of Primary Care & Population Health (RWM), the Department of Structural and Molecular Biology, University College London (KRB), London, United Kingdom (RWM); the London School of Hygiene and Tropical Medicine, London, United Kingdom (SE); the British Heart Foundation Glasgow Cardiovascular Research Centre, Faculty of Medicine (SP and NS) and General Practice and Primary Care, Division of Community Based Sciences (GW), University of Glasgow, Glasgow, United Kingdom; and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (SC).
St George's, University of London · GB
Funding
British Heart Foundation FS/05/095/19937British Heart Foundation FS05/125British Heart Foundation PG/13/66/30442British Heart Foundation PG97012British Heart Foundation PG97027British Heart Foundation PG98154British Heart Foundation RG/13/16/30528Cancer Research UKMedical Research Council G0600705Medical Research Council G9900686Medical Research Council MC_PC_15018Medical Research Council MC_U106179471Medical Research Council MC_UP_A100_1003Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/3Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Wellcome Trust 051187/Z/97/AWellcome Trust WT083431MF
Abstract
backgroundObservational studies showed that circulating L-ascorbic acid (vitamin C) is inversely associated with cardiometabolic traits. However, these studies were susceptible to confounding and reverse causation.
objectivesWe assessed the relation between L-ascorbic acid and 10 cardiometabolic traits by using a single nucleotide polymorphism in the solute carrier family 23 member 1 (SLC23A1) gene (rs33972313) associated with circulating L-ascorbic acid concentrations. The observed association between rs33972313 and cardiometabolic outcomes was compared with that expected given the rs33972313-L-ascorbic acid and L-ascorbic acid-outcome associations.
designA meta-analysis was performed in the following 5 independent studies: the British Women's Heart and Health Study (n = 1833), the MIDSPAN study (n = 1138), the Ten Towns study (n = 1324), the British Regional Heart Study (n = 2521), and the European Prospective Investigation into Cancer (n = 3737).
resultsWith the use of a meta-analysis of observational estimates, inverse associations were shown between L-ascorbic acid and systolic blood pressure, triglycerides, and the waist-hip ratio [the strongest of which was the waist-hip ratio (-0.13-SD change; 95% CI: -0.20-, -0.07-SD change; P = 0.0001) per SD increase in L-ascorbic acid], and a positive association was shown with high-density lipoprotein (HDL) cholesterol. The variation at rs33972313 was associated with a 0.18-SD (95% CI: 0.10-, 0.25-SD; P = 3.34 × 10⁻⁶) increase in L-ascorbic acid per effect allele. There was no evidence of a relation between the variation at rs33972313 and any cardiometabolic outcome. Although observed estimates were not statistically different from expected associations between rs33972313 and cardiometabolic outcomes, estimates for low-density lipoprotein cholesterol, HDL cholesterol, triglycerides, glucose, and body mass index were in the opposite direction to those expected.
conclusionsThe nature of the genetic association exploited in this study led to limited statistical application, but despite this, when all cardiometabolic traits were assessed, there was no evidence of any trend supporting a protective role of L-ascorbic acid. In the context of existing work, these results add to the suggestion that observational relations between L-ascorbic acid and cardiometabolic health may be attributable to confounding and reverse causation.
Indexed as
Polymorphism, Single NucleotideUp-RegulationAscorbic AcidBiomarkersCardiovascular DiseasesCholesterol, HDLEuropeGenetic Association StudiesHumansObservational Studies as TopicSodium-Coupled Vitamin C TransportersAscorbic AcidBiomarkersCholesterol, HDLSLC23A1 protein, humanSodium-Coupled Vitamin C Transporterscardiometabolic traitsconfoundinggenetic variantsl-ascorbic acidreverse causation
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