Evidence map›Paper›PMID 25527759›Full record

Trial reportThe American journal of clinical nutrition2015

Prospective association of fatty acids in the de novo lipogenesis pathway with risk of type 2 diabetes: the Cardiovascular Health Study.

Wenjie Ma, Jason H Y Wu, Qianyi Wang, Rozenn N Lemaitre, Kenneth J Mukamal, Luc Djoussé, Irena B King, Xiaoling Song, Mary L Biggs, Joseph A Delaney and 3 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 5 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 5 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Wenjie MaFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Jason H Y WuFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Qianyi WangFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Rozenn N LemaitreFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Kenneth J MukamalFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Luc DjousséFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Irena B KingFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Xiaoling SongFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Mary L BiggsFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Joseph A DelaneyFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Jorge R KizerFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
David S SiscovickFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Dariush MozaffarianFrom the Department of Epidemiology, Harvard School of Public Health, Boston, MA (WM, QW, and DM); the Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (DM); the Divisions of Aging (LD) and Cardiovascular Medicine and Channing Division of Network Medicine (DM), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; the Boston Veterans Affairs Healthcare System, Boston, MA (LD); the Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA (KJM); The George Institute for Global Health, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia (JHYW); the Cardiovascular Health Research Unit, Departments of Medicine (RNL and DSS), Epidemiology (DSS), and Biostatistics (MLB), and the Collaborative Health Studies Coordinating Center (JAD), University of Washington, Seattle, WA; the Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA (XS); the Department of Internal Medicine, University of New Mexico, Albuquerque, NM (IBK); and the Department of Medicine, Albert Einstein College of Medicine, Bronx, NY (JRK).
Tufts University · US

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
Determinants and Cardiovascular Consequences of Diabetes in Older AdultsR01HL094555 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ARNOLD, ALICE A., DJOUSSE, LUC · 2009 to 2012
$5.9M
Fatty Acids and Major Cardiovascular OutcomesR01HL085710 · NHLBI · TUFTS UNIVERSITY BOSTON · PI MOZAFFARIAN, DARIUSH · 2006 to 2016
$5.1M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
CHS-Transition PhaseN01HC55222 · NHLBI · PI , · 2007 to 2007
$575k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · HC · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1988 to 1999
–
CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085081 · HC · JOHNS HOPKINS UNIVERSITY · PI FRIED, LINDA P · 1988 to 2000
–
CORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–
NHLBI NIH HHS 2R01-HL-085710NHLBI NIH HHS HL080295NHLBI NIH HHS N01 HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS R01 HL085710NHLBI NIH HHS R01-HL-085710NHLBI NIH HHS R01-HL-094555NIA NIH HHS AG023629PHS HHS HHSN268200800007CPHS HHS HHSN268201200036C
6 · The paper itself

Abstract

backgroundExperimental evidence suggests that hepatic de novo lipogenesis (DNL) affects insulin homeostasis via synthesis of saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Few prospective studies have used fatty acid biomarkers to assess associations with type 2 diabetes.

objectivesWe investigated associations of major circulating SFAs [palmitic acid (16:0) and stearic acid (18:0)] and MUFA [oleic acid (18:1n-9)] in the DNL pathway with metabolic risk factors and incident diabetes in community-based older U.S. adults in the Cardiovascular Health Study. We secondarily assessed other DNL fatty acid biomarkers [myristic acid (14:0), palmitoleic acid (16:1n-7), 7-hexadecenoic acid (16:1n-9), and vaccenic acid (18:1n-7)] and estimated dietary SFAs and MUFAs.

designIn 3004 participants free of diabetes, plasma phospholipid fatty acids were measured in 1992, and incident diabetes was identified by medication use and blood glucose. Usual diets were assessed by using repeated food-frequency questionnaires. Multivariable linear and Cox regression were used to assess associations with metabolic risk factors and incident diabetes, respectively.

resultsAt baseline, circulating palmitic acid and stearic acid were positively associated with adiposity, triglycerides, inflammation biomarkers, and insulin resistance (P-trend < 0.01 each), whereas oleic acid showed generally beneficial associations (P-trend < 0.001 each). During 30,763 person-years, 297 incident diabetes cases occurred. With adjustment for demographics and lifestyle, palmitic acid (extreme-quintile HR: 1.89; 95% CI: 1.27, 2.83; P-trend = 0.001) and stearic acid (HR: 1.62; 95% CI: 1.09, 2.41; P-trend = 0.006) were associated with higher diabetes risk, whereas oleic acid was not significantly associated. In secondary analyses, vaccenic acid was inversely associated with diabetes (HR: 0.56; 95% CI: 0.38, 0.83; P-trend = 0.005). Other fatty acid biomarkers and estimated dietary SFAs or MUFAs were not significantly associated with incident diabetes.

conclusionsIn this large prospective cohort, circulating palmitic acid and stearic acid were associated with higher diabetes risk, and vaccenic acid was associated with lower diabetes risk. These results indicate a need for additional investigation of biological mechanisms linking specific fatty acids in the DNL pathway to the pathogenesis of diabetes.

Indexed as

LipogenesisUp-RegulationAgedBiomarkersCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHumansIncidenceLiverMalePalmitic AcidPhospholipidsPrevalenceBiomarkersPalmitic AcidPhospholipidsstearic acidStearic Acidsbiomarkerdiabetes mellitusdietfatty acidsmetabolism

Identifiers

PMID25527759
PMCPMC4266885
OpenAlexW2086943531

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.