ArticleThe Plant cell2014
The root hair "infectome" of Medicago truncatula uncovers changes in cell cycle genes and reveals a requirement for Auxin signaling in rhizobial infection.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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181 citing papers in PubMed, 372 citations in OpenAlex.
- A recently evolved Nodulin recruited by NIN for root hair rhizobial infection in Medicago truncatula.The New phytologist · 2026Article
- Unearthing Root Response Mechanisms to Soil Compaction in Legumes.Plant, cell & environment · 2026Review
- Transcriptomic Analysis Reveals the Role ofPlants (Basel, Switzerland) · 2026Article
- Spatiotemporal dynamics of ethylene biosynthesis shape infection and nodule initiation in Medicago truncatula.The Plant cell · 2026Article
- Transcriptomic Comparison of Soybean Roots Inoculated with Different Rhizobium Strains During Early Symbiosis.Plants (Basel, Switzerland) · 2026Article
- Identification of symbiotic nitrogen fixation-modulating factors in alfalfa and mechanism elucidation of MsHHO3.The Plant journal : for cell and molecular biology · 2026Article
- Symbiosis-associated UMAMIT transporters required for establishing efficient nitrogen fixation in Medicago truncatula.The New phytologist · 2026Article
- Advances in single-cell and spatial omics for studying symbiotic nitrogen fixation: comparative cellular and evolutionary perspectives.Genome biology · 2026Review
- Plant cell surface receptors.The Plant journal : for cell and molecular biology · 2026Review
- An NSP2-MYB module orchestrates flavonoid biosynthesis and nodule symbiosis.Current biology : CB · 2026Article
- Synergy between silicon and beneficial microorganisms enhances plant abiotic stress tolerance through rhizosphere restructuring and coordinated defense.Frontiers in plant science · 2026Review
- Root cell wall remodeling during symbiotic microbial colonization.Frontiers in plant science · 2026Review
- Hormone-modulated transcription factors orchestrating the root nodule symbiosis.Frontiers in plant science · 2026Review
- A legume cellulase required for rhizobial infection and colonization in root nodule symbiosis.Nature communications · 2025Article
- Article
- Enacting partner specificity in legume-rhizobia symbioses.aBIOTECH · 2025Review
- Applying conventional and cell-type-specific CRISPR/Cas9 genome editing in legume plants.aBIOTECH · 2025Review
- Genome-Wide Identification and Expression Analyses ofInternational journal of molecular sciences · 2025Article
- Function of Nodulation-Associated GmNARK Kinase in Soybean Alkali Tolerance.International journal of molecular sciences · 2025Article
- Understanding the Crucial Role of Phosphate and Iron Availability in Regulating Root Nodule Symbiosis.Plant & cell physiology · 2024Review
121 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Nitrogen-fixing rhizobia colonize legume roots via plant-made intracellular infection threads. Genetics has identified some genes involved but has not provided sufficient detail to understand requirements for infection thread development. Therefore, we transcriptionally profiled Medicago truncatula root hairs prior to and during the initial stages of infection. This revealed changes in the responses to plant hormones, most notably auxin, strigolactone, gibberellic acid, and brassinosteroids. Several auxin responsive genes, including the ortholog of Arabidopsis thaliana Auxin Response Factor 16, were induced at infection sites and in nodule primordia, and mutation of ARF16a reduced rhizobial infection. Associated with the induction of auxin signaling genes, there was increased expression of cell cycle genes including an A-type cyclin and a subunit of the anaphase promoting complex. There was also induction of several chalcone O-methyltransferases involved in the synthesis of an inducer of Sinorhizobium meliloti nod genes, as well as a gene associated with Nod factor degradation, suggesting both positive and negative feedback loops that control Nod factor levels during rhizobial infection. We conclude that the onset of infection is associated with reactivation of the cell cycle as well as increased expression of genes required for hormone and flavonoid biosynthesis and that the regulation of auxin signaling is necessary for initiation of rhizobial infection threads.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.