ArticleClinical journal of the American Society of Nephrology : CJASN2015
Long-term risk of upper gastrointestinal hemorrhage after advanced AKI.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 52 citations in OpenAlex.
- Long-Term Clinical Outcomes after Early Initiation of RRT in Critically Ill Patients with AKI.Journal of the American Society of Nephrology : JASN · 2018Trial
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- Regional citrate anticoagulation ensures safe and effective kidney replacement therapy in metformin-associated lactic acidosis.Clinical kidney journal · 2025Article
- Association between acute kidney injury, delirium and outcomes in patients with critical illness: a protocol for a systematic review.BMJ open · 2025Article
- State of the art: Renal recovery after AKI - from basic science to clinical practice.Intensive care medicine · 2025Review
- Trajectories of urea‑to‑creatinine ratio and risk of clinical outcomes in survivors of acute kidney disease: a population-based study.Clinical kidney journal · 2025Article
- Fibrinolytic Capacity and Risk of Bleeding in Intensive Care Patients with Acute Kidney Injury.TH open : companion journal to thrombosis and haemostasis · 2025Article
- Recovery Dynamics and Prognosis After Dialysis for Acute Kidney Injury.JAMA network open · 2024Article
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- When the kidneys hurt, the other organs suffer.Intensive care medicine · 2023Article
- Long-Term Outcome of Leptospirosis Infection with Acute Kidney Injury.Biomedicines · 2022Article
- When and why to start continuous renal replacement therapy in critically ill patients with acute kidney injury.Kidney research and clinical practice · 2021Article
- Hemodialysis Increases the Risk of Lower Gastrointestinal Bleeding and Angiodysplasia Bleeding: A Nationwide Population Study.Gastroenterology research and practice · 2020Article
- Article
- The aftermath of acute kidney injury: a narrative review of long-term mortality and renal function.Critical care (London, England) · 2019Review
- Long-term outcomes after extracorporeal membrane oxygenation in patients with dialysis-requiring acute kidney injury: A cohort study.PloS one · 2019Article
- Global epidemiology and outcomes of acute kidney injury.Nature reviews. Nephrology · 2018Review
- Effects of Statin Use in Advanced Chronic Kidney Disease Patients.Journal of clinical medicine · 2018Article
- Long-Term Outcomes in Patients with Incident Chronic Obstructive Pulmonary Disease after Acute Kidney Injury: A Competing-Risk Analysis of a Nationwide Cohort.Journal of clinical medicine · 2018Article
- Meglitinides increase the risk of hypoglycemia in diabetic patients with advanced chronic kidney disease: a nationwide, population-based study.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThere are few reports on temporary dialysis-requiring AKI as a risk factor for future upper gastrointestinal bleeding (UGIB). This study sought to explore the long-term association between dialysis-requiring AKI and UGIB. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This nationwide cohort study used data from the Taiwan National Health Insurance Research Database. Patients who recovered from dialysis-requiring AKI and matched controls were selected from hospitalized patients age ≥18 years between 1998 and 2006. The cumulative incidences of long-term de novo UGIB were calculated, and the risk factors of UGIB and mortality were identified using time-varying Cox proportional hazard models adjusted for subsequent CKD and ESRD after AKI.
resultsA total of 4565 AKI-recovery patients and the same number of matched patients without AKI were analyzed. After a median follow-up time of 2.33 years (interquartile range, 0.97-4.81 years), the incidence rates of UGIB were 50 (by stringent criterion) and 69 (by lenient criterion) per 1000 patient-years in the AKI-recovery group and 31 (by stringent criterion) and 48 (by lenient criterion) per 1000 patient-years in the non-AKI group (both P<0.001). When compared with patients in the non-AKI group, the multivariate hazard ratio (HR) for UGIB was 1.30 (95% confidence interval [95% CI], 1.14 to 1.48) for dialysis-requiring AKI, 1.83 (95% CI, 1.53 to 2.20) for time-varying CKD, and 2.31 (95% CI, 1.92 to 2.79) for time-varying ESRD (all P<0.001). Finally, the risk for long-term mortality increased after UGIB (HR, 1.24; 95% CI, 1.12 to 1.38) and dialysis-requiring AKI (HR, 1.66; 95% CI, 1.54 to 1.78).
conclusionsRecovery from dialysis-requiring AKI was associated with future UGIB and mortality.
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