Evidence map›Paper›PMID 25527561›Full record

ArticleHaematologica2015

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia.

Antonis Dagklis, Daphnie Pauwels, Idoya Lahortiga, Ellen Geerdens, Emilie Bittoun, Barbara Cauwelier, Thomas Tousseyn, Anne Uyttebroeck, Johan Maertens, Gregor Verhoef and 2 more

Abstract readLetter
In one paragraph

Article in Haematologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  12. Sonidegib, a Smoothened Inhibitor, Promotes Apoptosis and Suppresses Proliferation of Natural Killer/T-Cell Lymphoma.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonis DagklisCenter for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
Daphnie PauwelsCenter for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
Idoya LahortigaCenter for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
Ellen GeerdensCenter for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven.
Emilie BittounDepartment of Pathology UZ Leuven.
Barbara CauwelierLaboratory Department of Hematology, AZ St Jan, Brugge.
Thomas TousseynDepartment of Pathology UZ Leuven.
Anne UyttebroeckPediatric oncology, UZ Leuven.
Johan MaertensHematology Department, UZ Leuven, Belgium.
Gregor VerhoefHematology Department, UZ Leuven, Belgium.
Peter VandenbergheCenter for Human Genetics, KU Leuven.
Jan CoolsCenter for the Biology of the Disease, VIB, Leuven Center for Human Genetics, KU Leuven Jan.cools@cme.vib-kuleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAdultAnimalsBase SequenceChildFemaleGene ExpressionHEK293 CellsHumansKruppel-Like Transcription FactorsMaleMice, Inbred BALB CMolecular Sequence DataMutationNerve Tissue ProteinsPatched ReceptorsGLI1 protein, humanGLI3 protein, humanKruppel-Like Transcription FactorsNerve Tissue ProteinsPatched ReceptorsReceptors, Cell SurfaceReceptors, G-Protein-CoupledSmoothened ReceptorSMO protein, humanTranscription FactorsZinc Finger Protein GLI1Zinc Finger Protein Gli3Hedgehog pathwayleukemiaoncogenesignaling

Identifiers

PMID25527561
PMCPMC4349289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.