ArticleGenetics2015
Neuropeptide receptors NPR-1 and NPR-2 regulate Caenorhabditis elegans avoidance response to the plant stress hormone methyl salicylate.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Differential modulation of C. elegans motor behavior by NALCN and two-pore domain potassium channels.PLoS genetics · 2022Article
- Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response.PLoS genetics · 2022Article
- Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation.Journal of molecular biology · 2021Article
- Measurement of the Effects of Metals on Taxis-to-Food Behavior in Caenorhabditis elegans.Current protocols · 2021Article
- Overview of Chemotaxis Behavior Assays in Caenorhabditis elegans.Current protocols · 2021Article
- Phylum-Spanning Neuropeptide GPCR Identification and Prioritization: Shaping Drug Target Discovery Pipelines for Nematode Parasite Control.Frontiers in endocrinology · 2021Article
- Worms avoid a cat sensed repellent.microPublication biology · 2020Article
- LAITOR4HPC: A text mining pipeline based on HPC for building interaction networks.BMC bioinformatics · 2020Article
- The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To RegulateG3 (Bethesda, Md.) · 2020Article
- A Chemosensory GPCR as a Potential Target to Control the Root-Knot NematodeMolecules (Basel, Switzerland) · 2019Article
- Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system.Cell communication and signaling : CCS · 2019Article
- FLP-18 Functions through the G-Protein-Coupled Receptors NPR-1 and NPR-4 to Modulate Reversal Length inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neuropeptidergic Signaling and Active Feeding State Inhibit Nociception in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Methyl salicylate (MeSa) is a stress hormone released by plants under attack by pathogens or herbivores . MeSa has been shown to attract predatory insects of herbivores and repel pests. The molecules and neurons underlying animal response to MeSa are not known. Here we found that the nematode Caenorhabditis elegans exhibits a strong avoidance response to MeSa, which requires the activities of two closely related neuropeptide receptors NPR-1 and NPR-2. Molecular analyses suggest that NPR-1 expressed in the RMG inter/motor neurons is required for MeSa avoidance. An NPR-1 ligand FLP-18 is also required. Using a rescuing npr-2 promoter to drive a GFP transgene, we identified that NPR-2 is expressed in multiple sensory and interneurons. Genetic rescue experiments suggest that NPR-2 expressed in the AIZ interneurons is required for MeSa avoidance. We also provide evidence that the AWB sensory neurons might act upstream of RMGs and AIZs to detect MeSa. Our results suggest that NPR-2 has an important role in regulating animal behavior and that NPR-1 and NPR-2 act on distinct interneurons to affect C. elegans avoidance response to MeSa.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.