ReviewJournal of dental research2015
Gingival wound healing: an essential response disturbed by aging?
Review in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Stability of biomaterials used in adjunct to coronally advanced flap: A systematic review and network meta-analysis.Clinical and experimental dental research · 2022Pooled it
- Effectiveness of connective tissue graft substitutes for the treatment of gingival recessions compared with coronally advanced flap: a network meta-analysis.Clinical oral investigations · 2020Pooled it
- Green tea and hyaluronic acid gel enhance fibroblast activation and improves the gingival healing post-third molar extraction.Scientific reports · 2024Trial
- Trial
- Age-related local versus systemic early phase wound healing dynamics following free gingival graft harvest.Journal of periodontology · 2026Article
- Histological analysis of periodontal tissues in patients with autoimmune diseases: a comparative cross-sectional study of inflammatory cell infiltration and epithelial barrier function.BMC oral health · 2026Article
- The Effect of Periodontally Accelerated Osteogenic Orthodontics on Periodontal Phenotypes in Adult Patients With Skeletal Class II Malocclusion: A Retrospective Cohort Study.International dental journal · 2026Article
- Evaluation of Discoidin domain receptor 1 (DDR1) in junctional epithelial permeability and wound healing.Journal of periodontology · 2026Article
- Innovative biomaterials in promoting intraoral wound healing: Mechanisms, applications, and challenges.Materials today. Bio · 2025Review
- Polynucleotide with cross-linked hyaluronic acid reduces inflammation and increases collagen synthesis.Journal of periodontal & implant science · 2025Article
- Biological processes and factors involved in soft and hard tissue healing.Periodontology 2000 · 2025Review
- Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa.Frontiers in pharmacology · 2025Article
- Early wound healing at 1 week postoperatively in periodontal tissue regeneration therapy: enamel matrix derivative versus recombinant human fibroblast growth factor.Journal of periodontal & implant science · 2024Article
- Comparison of the Effects of Mucosa Tissue Healing with Chlorhexidine Digluconate and Choline Salicylate in Patients Wearing a Removable Prosthetic Restoration-A RCT.Clinics and practice · 2024Article
- Development of a Coculture Model for Assessing Competing Host Mammalian Cell and Bacterial Attachment on Zirconia versus Titanium.ACS biomaterials science & engineering · 2024Article
- Decellularized extracellular matrix derived from dental pulp stem cells promotes gingival fibroblast adhesion and migration.BMC oral health · 2024Article
- Comparison of early wound healing using modified papilla preservation technique between enamel matrix derivative and recombinant human fibroblast growth factor.Journal of periodontal & implant science · 2024Article
- Update on suspensory suture techniques in reconstructive periodontal surgeries.Oral and maxillofacial surgery · 2024Review
- Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.Molecular oral microbiology · 2024Article
- Histological and Immunohistochemical Evaluation of Rh-BMP2: Effect on Gingival Healing Acceleration and Proliferation of Human Epithelial Cells.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing may also play an important role during cell and tissue reaction to long-term injury, as it may occur during inflammatory responses and cancer. Recent experimental data have shown that gingival wound healing is severely affected by the aging process. These defects may alter distinct phases of the wound-healing process, including epithelial migration, granulation tissue formation, and tissue remodeling. The cellular and molecular defects that may explain these deficiencies include several biological responses such as an increased inflammatory response, altered integrin signaling, reduced growth factor activity, decreased cell proliferation, diminished angiogenesis, reduced collagen synthesis, augmented collagen remodeling, and deterioration of the proliferative and differentiation potential of stem cells. In this review, we explore the cellular and molecular basis of these defects and their possible clinical implications.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.