ArticleBMC genomics2014
Core and accessory genome architecture in a group of Pseudomonas aeruginosa Mu-like phages.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Genomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEpFrontiers in microbiology · 2025Article
- Soil Giant Phage: Genome and Biological Characteristics ofInternational journal of molecular sciences · 2024Article
- Complete genome sequences of StopSmel and Aussie, two Mu-like bacteriophages ofMicrobiology resource announcements · 2024Article
- Tailless and filamentous prophages are predominant in marine Vibrio.The ISME journal · 2024Article
- Unexplored diversity and ecological functions of transposable phages.The ISME journal · 2023Article
- Identifying the core genome of the nucleus-forming bacteriophage family and characterization of Erwinia phage RAY.Cell reports · 2023Article
- Distribution and molecular evolution of the anti-CRISPR family AcrIF7.PLoS biology · 2023Article
- Transcriptional analysis in bacteriophage Fc02 ofFrontiers in microbiology · 2023Article
- Transposable Prophages in Leptospira: An Ancient, Now Diverse, Group Predominant in Causative Agents of Weil's Disease.International journal of molecular sciences · 2021Article
- Characterization and Genomic Analysis of ɸSHP3, a New Transposable Bacteriophage Infecting Stenotrophomonas maltophilia.Journal of virology · 2021Article
- Article
- The Concerted Action of Two B3-Like Prophage Genes Excludes Superinfecting Bacteriophages by Blocking DNA Entry into Pseudomonas aeruginosa.Journal of virology · 2020Article
- A Phage-Like Plasmid CarryingFrontiers in microbiology · 2019Article
- Novel phages of healthy skin metaviromes from South Africa.Scientific reports · 2018Article
- Article
- Characterization and Genomic Analyses ofFrontiers in microbiology · 2018Article
- The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.Annual review of virology · 2017Review
- Genomic, proteomic and bioinformatic analysis of two temperate phages in Roseobacter clade bacteria isolated from the deep-sea water.BMC genomics · 2017Article
- Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model.BMC microbiology · 2017Article
- Selection of Functional Quorum Sensing Systems by Lysogenic Bacteriophages inFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteriophages that infect the opportunistic pathogen Pseudomonas aeruginosa have been classified into several groups. One of them, which includes temperate phage particles with icosahedral heads and long flexible tails, bears genomes whose architecture and replication mechanism, but not their nucleotide sequences, are like those of coliphage Mu. By comparing the genomic sequences of this group of P. aeruginosa phages one could draw conclusions about their ontogeny and evolution.
resultsTwo newly isolated Mu-like phages of P. aeruginosa are described and their genomes sequenced and compared with those available in the public data banks. The genome sequences of the two phages are similar to each other and to those of a group of P. aeruginosa transposable phages. Comparing twelve of these genomes revealed a common genomic architecture in the group. Each phage genome had numerous genes with homologues in all the other genomes and a set of variable genes specific for each genome. The first group, which comprised most of the genes with assigned functions, was named "core genome", and the second group, containing mostly short ORFs without assigned functions was called "accessory genome". Like in other phage groups, variable genes are confined to specific regions in the genome.
conclusionBased on the known and inferred functions for some of the variable genes of the phages analyzed here, they appear to confer selective advantages for the phage survival under particular host conditions. We speculate that phages have developed a mechanism for horizontally acquiring genes to incorporate them at specific loci in the genome that help phage adaptation to the selective pressures imposed by the host.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.