ArticleClinical reviews in allergy & immunology2016
Hereditary Angioedema Attacks: Local Swelling at Multiple Sites.
Article in Clinical reviews in allergy & immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Hereditary Angioedema: The Clinical Picture of Excessive Contact Activation.Seminars in thrombosis and hemostasis · 2024Review
- Assessment and management of disease burden and quality of life in patients with hereditary angioedema: a consensus report.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Review
- Angioedema without wheals: a clinical update.Balkan medical journal · 2021Article
- Rediscovery of a forgotten disease: Hereditary Angioedema.Balkan medical journal · 2021Article
- Evaluation of retinal microvascular perfusion in hereditary angioedema: a case-control study.Orphanet journal of rare diseases · 2020Article
- Hereditary angioedema: Linking complement regulation to the coagulation system.Research and practice in thrombosis and haemostasis · 2019Review
- The complex alteration in the network of IL-17-type cytokines in patients with hereditary angioedema.Clinical and experimental medicine · 2018Article
- Intermittent C1-Inhibitor Deficiency Associated with Recessive Inheritance: Functional and Structural Insight.Scientific reports · 2018Article
- Pediatric Hereditary Angioedema as a Cause of Acute Compartment Syndrome of the Hand and Forearm: A Case Report.Hand (New York, N.Y.) · 2017Article
- Bradykinin: Inflammatory Product of the Coagulation System.Clinical reviews in allergy & immunology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hereditary angioedema (HAE) patients experience recurrent local swelling in various parts of the body including painful swelling of the intestine and life-threatening laryngeal oedema. Most HAE literature is about attacks located in one anatomical site, though it is mentioned that HAE attacks may also involve multiple anatomical sites simultaneously. A detailed description of such multi-location attacks is currently lacking. This study investigated the occurrence, severity and clinical course of HAE attacks with multiple anatomical locations. HAE patients included in a clinical database of recombinant human C1-inhibitor (rhC1INH) studies were evaluated. Visual analog scale scores filled out by the patients for various symptoms at various locations and investigator symptoms scores during the attack were analysed. Data of 219 eligible attacks in 119 patients was analysed. Thirty-three patients (28%) had symptoms at multiple locations in anatomically unrelated regions at the same time during their first attack. Up to five simultaneously affected locations were reported. The observation that severe HAE attacks often affect multiple sites in the body suggests that HAE symptoms result from a systemic rather than from a local process as is currently believed.
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