Evidence map›Paper›PMID 25527201›Full record

ArticleOrphanet journal of rare diseases2014

Relapsing polychondritis: clinical presentations, disease activity and outcomes.

Aman Sharma, Arjun Dutt Law, Pradeep Bambery, Vinay Sagar, Ajay Wanchu, Varun Dhir, Rajesh Vijayvergiya, Kusum Sharma, Ashok Gupta, Naresh K Panda and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Orphanet journal of rare diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  7. Review
  8. Article
  9. Multiple Cranial-Nerve Palsies: An Unusual Culprit.Journal of clinical neurology (Seoul, Korea) · 2018
    Article
  10. Review
  11. Article
  12. Relapsing polychondritis: a chameleon among orphan diseases.Wiener medizinische Wochenschrift (1946) · 2017
    Review
  13. Connective Tissue Disorder-Associated Vasculitis.Current rheumatology reports · 2016
    Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Aman SharmaDepartment of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. amansharma74@yahoo.com.
Arjun Dutt LawDepartment of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. arjun.d.law@gmail.com.
Pradeep BamberyUniversity of Queensland, Bundaberg Hospital, Bundaberg, Australia. pradeepbambery@hotmail.com.
Vinay SagarDepartment of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. vinaysagarleo@gmail.com.
Ajay WanchuDivision of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, Oregon, USA. awanchu@yahoo.com.
Varun DhirDepartment of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. varundhir@gmail.com.
Rajesh VijayvergiyaDepartment of Cardiology, Postgraduate Institute of medical education and research, Chandigarh, India. rajeshvijay999@hotmail.com.
Kusum SharmaDepartment of Medical Microbiology, Postgraduate Institute of medical education and research, Chandigarh, India. sharmakusum9@yahoo.co.in.
Ashok GuptaDepartment of Otorhinolaryngology, Postgraduate Institute of medical education and research, Chandigarh, India. akgpgi@hotmail.com.
Naresh K PandaDepartment of Otorhinolaryngology, Postgraduate Institute of medical education and research, Chandigarh, India. npanda59@yahoo.co.in.
Surjit SinghDepartment of Internal Medicine, Postgraduate Institute of medical education and research, Chandigarh, India. surjit51@hotmail.com.
Post Graduate Institute of Medical Education and Research · INOregon Health & Science University · USUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelapsing polychondritis is a rare disease characterised by inflammation of cartilaginous and proteoglycan rich structures. As there are only a few published single centre case series from all across the world, we describe our experience with 26 patients at a tertiary centre in north India.

methodsA retrospective study with all patients meeting Damiani and Levine's modification of McAdam's diagnostic criteria. Clinical details, investigations, disease activity assessment [(Relapsing Polychondritis Disease Activity Index (RPDAI)], treatment and outcomes were recorded.

resultsTen men and sixteen women (median age 45 years) met the diagnostic criteria. Auricular chondritis (96%), arthritis (54%), hearing impairment (42%), ocular (42%), dermal (26%), cardiovascular (11%) and laryngotracheal involvement (11%) characterized the clinical presentations. The median RPDAI was 31 (range 9-66). Two patients died during observation. Overall survival was 92.3% (median survival 13.5 years).

conclusionsApart from reduced laryngotracheal involvement, RP in India was clinically similar to recorded patterns elsewhere.

Indexed as

AdolescentAdultAgedFemaleHumansImmunosuppressive AgentsMaleMiddle AgedPolychondritis, RelapsingRetrospective StudiesTreatment OutcomeYoung AdultImmunosuppressive Agents

Identifiers

PMID25527201
PMCPMC4302515
OpenAlexW2160573353

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.