Evidence map›Paper›PMID 25527097›Full record

ArticleBioinformatics (Oxford, England)2015

CDvist: a webserver for identification and visualization of conserved domains in protein sequences.

Ogun Adebali, Davi R Ortega, Igor B Zhulin

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Evolutionary history of MEK1 illuminates the nature of deleterious mutations.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ogun AdebaliComputer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Davi R OrtegaComputer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.
Igor B ZhulinComputer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37861, USA and Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA.

Funding

Computational Genomics of Signal TransductionR01GM072285 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI JOULINE, IGOR B. · 2004 to 2018
$3.2M
NIGMS NIH HHS GM072285NIGMS NIH HHS R01 GM072285
6 · The paper itself

Abstract

summaryIdentification of domains in protein sequences allows their assigning to biological functions. Several webservers exist for identification of protein domains using similarity searches against various databases of protein domain models. However, none of them provides comprehensive domain coverage while allowing bulk querying and their visualization schemes can be improved. To address these issues, we developed CDvist (a comprehensive domain visualization tool), which combines the best available search algorithms and databases into a user-friendly framework. First, a given protein sequence is matched to domain models using high-specificity tools and only then unmatched segments are subjected to more sensitive algorithms resulting in a best possible comprehensive coverage. Bulk querying and rich visualization and download options provide improved functionality to domain architecture analysis. AVAILABILITY AND IMPLEMENTATION: Freely available on the web at http://cdvist.utk.edu CONTACT: oadebali@vols.utk.edu or ijouline@utk.edu.

Indexed as

Protein Structure, TertiarySoftwareAlgorithmsAmino Acid SequenceComputer GraphicsConserved SequenceDatabases, ProteinInternetSequence Analysis, Protein

Identifiers

PMID25527097
PMCPMC4410658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.