ArticleGenome biology and evolution2014
The secreted proteins of Achlya hypogyna and Thraustotheca clavata identify the ancestral oomycete secretome and reveal gene acquisitions by horizontal gene transfer.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 30 citations in OpenAlex.
- Eukaryotic metagenome-assembled genomes recovered from deep metagenomic sequencing of the seagrass,Microbial genomics · 2026Article
- How Saprolegniales became successful parasites.PLoS pathogens · 2026Article
- Duplication and neofunctionalization of a horizontally transferred xyloglucanase as a facet of the Red Queen coevolutionary dynamic.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Duplication and neofunctionalization of a horizontally-transferred xyloglucanase as a facet of the red queen co-evolutionary dynamic.bioRxiv : the preprint server for biology · 2023Article
- Predicting Lifestyle from Positive Selection Data and Genome Properties in Oomycetes.Pathogens (Basel, Switzerland) · 2021Article
- Comparative analyses of saprotrophy in Salisapilia sapeloensis and diverse plant pathogenic oomycetes reveal lifestyle-specific gene expression.FEMS microbiology ecology · 2020Article
- A Global Survey of Carbohydrate Esterase Families 1 and 10 in Oomycetes.Frontiers in genetics · 2020Article
- Contrasted Micro-Eukaryotic Diversity Associated with Sphagnum Mosses in Tropical, Subtropical and Temperate Climatic Zones.Microbial ecology · 2019Article
- Environment-dependent fitness gains can be driven by horizontal gene transfer of transporter-encoding genes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Ancestral Function and Diversification of a Horizontally Acquired Oomycete Carboxylic Acid Transporter.Molecular biology and evolution · 2018Article
- Comparative genomic analysis of the 'pseudofungus'Open biology · 2018Article
- Glycoside hydrolases family 20 (GH20) represent putative virulence factors that are shared by animal pathogenic oomycetes, but are absent in phytopathogens.BMC microbiology · 2016Article
- Laterally Transferred Gene Recruited as a Venom in Parasitoid Wasps.Molecular biology and evolution · 2016Article
- The role of horizontal gene transfer in the evolution of the oomycetes.PLoS pathogens · 2015Article
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5 authors at 3 institutions in 3 countries.
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Abstract
Saprotrophic and parasitic microorganisms secrete proteins into the environment to breakdown macromolecules and obtain nutrients. The molecules secreted are collectively termed the "secretome" and the composition and function of this set of proteins varies depending on the ecology, life cycle, and environment of an organism. Beyond the function of nutrient acquisition, parasitic lineages must also secrete molecules to manipulate their host. Here, we use a combination of de novo genome and transcriptome sequencing and bioinformatic identification of signal peptides to identify the putative secreted proteome of two oomycetes, the facultative parasite Achlya hypogyna and free-living Thraustotheca clavata. By comparing the secretomes of these saprolegnialean oomycetes with that of eight other oomycetes, we were able to characterize the evolution of this protein set across the oomycete clade. These species span the last common ancestor of the two major oomycete families allowing us to identify the ancestral secretome. This putative ancestral secretome consists of at least 84 gene families. Only 11 of these gene families are conserved across all 10 secretomes analyzed and the two major branches in the oomycete radiation. Notably, we have identified expressed elicitin-like effector genes in the saprotrophic decomposer, T. clavata. Phylogenetic analyses show six novel horizontal gene transfers to the oomycete secretome from bacterial and fungal donor lineages, four of which are specific to the Saprolegnialeans. Comparisons between free-living and pathogenic taxa highlight the functional changes of oomycete secretomes associated with shifts in lifestyle.
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