ArticleBiological psychiatry2015
Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain.
Article in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
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Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition.Journal of affective disorders · 2023Trial
- A Neurocomputational Account of How Inflammation Enhances Sensitivity to Punishments Versus Rewards.Biological psychiatry · 2016Trial
- MC BTS: Simultaneously Resolving Magnetization Transfer Effect and Relaxation for Multiple Components.Magnetic resonance in medicine · 2026Article
- Macrostructural, microstructural, and cellular effects of neuroinflammation on the mouse brain.Brain, behavior, & immunity - health · 2026Article
- Multiparametric MRI assessment of acute neuroinflammation in a murine model of peripheral LPS stimulation.BMC medical imaging · 2025Article
- Myelin mapping in patients with rheumatoid arthritis-related fatigue: a TBSS-MTR study of integrity.BJR open · 2025Article
- Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn's disease patients: explorative findings from a 7T MRS study.Frontiers in human neuroscience · 2025Article
- Microstructural asymmetry in the human cortex.Nature communications · 2024Article
- Effect of serum concentrations of IL-6 and TNF-α on brain structure in anorexia nervosa: a combined cross-sectional and longitudinal study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Understanding the mechanisms of fatigue in multiple sclerosis: linking interoception, metacognition and white matter dysconnectivity.Brain communications · 2024Article
- Molecular pathways underlying lung-brain axis signaling in asthma: Relevance for psychopathology and neuroinflammation.The Journal of allergy and clinical immunology · 2024Article
- Immune mechanisms of depression in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Immunoception: the insular cortex perspective.Cellular & molecular immunology · 2023Review
- Insular dysfunction of interoception in major depressive disorder: from the perspective of neuroimaging.Frontiers in psychiatry · 2023Review
- Insula and the Immune System: More than mere Co-existence?Neuroscience bulletin · 2022Article
- Article
- Apolipoprotein ε4 modifies obesity-related atrophy in the hippocampal formation of cognitively healthy adults.Neurobiology of aging · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSystemic inflammation impairs brain function and is increasingly implicated in the etiology of common mental illnesses, particularly depression and Alzheimer's disease. Immunotherapies selectively targeting proinflammatory cytokines demonstrate efficacy in a subset of patients with depression. However, efforts to identify patients most vulnerable to the central effects of inflammation are hindered by insensitivity of conventional structural magnetic resonance imaging.
methodsWe used quantitative magnetization transfer (qMT) imaging, a magnetic resonance imaging technique that enables quantification of changes in brain macromolecular density, together with experimentally induced inflammation to investigate effects of systemic inflammatory challenge on human brain microstructure. Imaging with qMT was performed in 20 healthy participants after typhoid vaccination and saline control injection. An additional 20 participants underwent fluorodeoxyglucose positron emission tomography following the same inflammatory challenge.
resultsThe qMT data demonstrated that inflammation induced a rapid change in brain microstructure, reflected in increased magnetization exchange from free (water) to macromolecular-bound protons, within a discrete region of insular cortex implicated in representing internal physiologic states including inflammation. The functional significance of this change in insular microstructure was demonstrated by correlation with inflammation-induced fatigue and fluorodeoxyglucose positron emission tomography imaging, which revealed increased resting glucose metabolism within this region following the same inflammatory challenge.
conclusionsTogether these observations highlight a novel structural biomarker of the central physiologic and behavioral effects of mild systemic inflammation. The widespread clinical availability of magnetic resonance imaging supports the viability of qMT imaging as a clinical biomarker in trials of immunotherapeutics, both to identify patients vulnerable to the effects of systemic inflammation and to monitor neurobiological responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.