Evidence map›Paper›PMID 25526950›Full record

ArticleWorld journal of surgical oncology2014

Therapeutic effect of intratumoral injections of dendritic cells for locally recurrent gastric cancer: a case report.

Masanori Kobayashi, Tomoyo Sakabe, Asako Chiba, Akihito Nakajima, Masato Okamoto, Shigetaka Shimodaira, Yoshikazu Yonemitsu, Yuta Shibamoto, Noboru Suzuki, Masaki Nagaya and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in World journal of surgical oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Dendritic cell-based vaccine for pancreatic cancer in Japan.World journal of gastrointestinal pharmacology and therapeutics · 2016
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Masanori Kobayashi
Tomoyo Sakabe
Asako Chiba
Akihito Nakajima
Masato Okamoto
Shigetaka Shimodaira
Yoshikazu Yonemitsu
Yuta Shibamoto
Noboru Suzuki
Masaki NagayaSeren Clinic Tokyo, Isokai, 2-10-2 Shirokanedai, Minato-ku, Tokyo 108-0071, Japan. m2nagaya@marianna-u.ac.jp.
DC-vaccine study group at the Japan Society of Innovative Cell Therapy (J-SICT)
Santen (Japan) · JPSt. Marianna University School of Medicine · JPSystems Biology Institute · JPKeio University Hospital · JPKyushu University · JPMizuho (Japan) · JPShinshu University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An 80-year-old man with a history of gastric cancer and pulmonary emphysema underwent a distal gastrectomy for gastric cancer in 1997. In 2010, an endoscopic examination revealed a depressed-type lesion at the oral side of the anastomosis, which was diagnosed as signet-ring adenocarcinoma. Surgical management was considered, but was rejected because of obstructive and restrictive respiratory events. Chemotherapy was terminated because of adverse events. Endoscopy was used to administer intratumoral injections of dendritic cells (DCs) targeting synthesized peptides of Wilms tumor 1 (WT1) and mucin 1, cell-surface associated (MUC1). An immunohistochemical analysis of the tumor samples indicated positivity for WT1 and MUC1. One month after seven cycles of DC had been administered (between November 2010 and April 2011), no suspicious lesions were evident, and his biopsy results were normal. The patient has been in remission for 30 months. Intratumoral injections of DCs showed therapeutic effects in this patient, who could not undergo endoscopic submucosal dissection or surgery.

Indexed as

AdenocarcinomaAged, 80 and overDendritic CellsHumansImmunotherapyMaleMucin-1Neoplasm Recurrence, LocalPeptide FragmentsPrognosisStomach NeoplasmsWT1 ProteinsMucin-1Peptide FragmentsWT1 protein, humanWT1 Proteins

Identifiers

PMID25526950
PMCPMC4320508
OpenAlexW2115706719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.