ReviewReviews in endocrine & metabolic disorders2015
Regulation of energy balance by inflammation: common theme in physiology and pathology.
Review in Reviews in endocrine & metabolic disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
86 citing papers in PubMed, 170 citations in OpenAlex.
- A Novel Inflammation and Insulin Resistance Related Indicator to Predict the Survival of Patients With Cancer.Frontiers in endocrinology · 2022Trial
- Reduced Albumin Concentration Predicts Weight Gain and HigherFrontiers in endocrinology · 2021Trial
- Dietary interaction of soybean oil and high starch impairs growth performance via metabolic-inflammatory dysregulation in Siberian sturgeon (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- The Mediating Role of Hypoalbuminemia in the Association Between Frailty and Poor Outcomes in Stroke Patients.Nursing open · 2026Article
- Algae-specific immune modulation influences responses to heat and pathogen challenge in a symbiotic coral.Science advances · 2026Article
- Endogenous Lipid Signals in Energy Homeostasis and Fibrosis.Biomolecules · 2026Review
- Article
- Transcriptomic Analysis and Machine Learning Identify Cross-Pathogen Biomarkers for Bacterial and Parasitic Infections in Silver Pomfret (Animals : an open access journal from MDPI · 2026Article
- Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response.BMC psychiatry · 2026Article
- Exploring Paraprobiotics and Postbiotics: A New Frontier in Obesity Treatment via Gut Microbiota Modulation.Current nutrition reports · 2026Review
- Malnutrition in maintenance hemodialysis: Prevalence, patterns, and clinical implications in Bangladesh.PloS one · 2026Article
- Sex-Specific Basal Metabolic Rate and NAFLD Risk: The Multi-Population Observational and Mendelian Randomization Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Mechanism of glycolysis-pyrolysis crosstalk driving vicious circle of intervertebral disc degeneration.Apoptosis : an international journal on programmed cell death · 2025Article
- Surgical Stress Response: A Physiological Review of the Endocrine, Immune, and Metabolic Changes.Cureus · 2025Review
- Acute and chronic nasal inflammation induces lymphangiogenesis in the olfactory mucosa in mice.Brain, behavior, & immunity - health · 2025Article
- Application of an Ecological Approach to Assessment of Nutrition in School-Aged Children-A Report from the "Biomarkers of Nutrition for Development: Knowledge Indicating Dietary Sufficiency (BOND-KIDS)" Project Working Group 3.The Journal of nutrition · 2025Review
- Eating disorders, nutrient intake, and cardiometabolic risks: a cross-sectional study in Turkish adults.BMC public health · 2025Article
- Cathepsins: Emerging targets in the tumor ecosystem to overcome cancers.Seminars in cancer biology · 2025Review
- Biomarkers associated with cancer-related anorexia in lung cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Impaired inflammatory resolution with severe SARS-CoV-2 infection in leptin knock out obese hamster.iScience · 2025Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inflammation regulates energy metabolism in both physiological and pathological conditions. Pro-inflammatory cytokines involves in energy regulation in several conditions, such as obesity, aging (calorie restriction), sports (exercise), and cancer (cachexia). Here, we introduce a view of integrative physiology to understand pro-inflammatory cytokines in the control of energy expenditure. In obesity, chronic inflammation is derived from energy surplus that induces adipose tissue expansion and adipose tissue hypoxia. In addition to the detrimental effect on insulin sensitivity, pro-inflammatory cytokines also stimulate energy expenditure and facilitate adipose tissue remodeling. In caloric restriction (CR), inflammatory status is decreased by low energy intake that results in less energy supply to immune cells to favor energy saving under caloric restriction. During physical exercise, inflammatory status is elevated due to muscle production of pro-inflammatory cytokines, which promote fatty acid mobilization from adipose tissue to meet the muscle energy demand. In cancer cachexia, chronic inflammation is elevated by the immune response in the fight against cancer. The energy expenditure from chronic inflammation contributes to weight loss. Immune tolerant cancer cells gains more nutrients during the inflammation. In these conditions, inflammation coordinates energy distribution and energy demand between tissues. If the body lacks response to the pro-inflammatory cytokines (Inflammation Resistance), the energy metabolism will be impaired leading to an increased risk for obesity. In contrast, super-induction of the inflammation activity leads to weight loss and malnutrition in cancer cachexia. In summary, inflammation is a critical component in the maintenance of energy balance in the body. Literature is reviewed in above fields to support this view.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.