Evidence map›Paper›PMID 25526831›Full record

Trial reportBehavior therapy2015

Cognitive behavioral therapy for early adolescents with autism spectrum disorders and clinical anxiety: a randomized, controlled trial.

Jeffrey J Wood, Jill Ehrenreich-May, Michael Alessandri, Cori Fujii, Patricia Renno, Elizabeth Laugeson, John C Piacentini, Alessandro S De Nadai, Elysse Arnold, Adam B Lewin and 2 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Behavior therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05031364 (Effectiveness of Evidence-Based Mental Health Practices for Youth With Autism Supported by Online Consultation to Practitioners in Community and Navy Clinics), which is not on this map. Cited by 73 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 9 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05031364 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effectiveness of Evidence-Based Mental Health Practices for Youth With Autism Supported by Online Consultation to Practitioners in Community and Navy Clinics

TypeinterventionalSponsorUniversity of California, Los AngelesRan2021 to 2026Enrolled100ConditionsAutismArmsBehavioral Interventions for Anxiety in Children with Autism (BIACA), Treatment-as-Usual Supplemented by Internet-Based Self-Instruction (MEYA)
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 9 syntheses or guidelines pooled it, 226 citations in OpenAlex.

  1. Meta-analysis of Psychotherapy for Autistic Youth.Child psychiatry and human development · 2026
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jeffrey J WoodUCLA. Electronic address: jwood@gseis.ucla.edu.
Jill Ehrenreich-MayUniversity of Miami.
Michael AlessandriUniversity of Miami.
Cori FujiiUCLA.
Patricia RennoUCLA.
Elizabeth LaugesonUCLA.
John C PiacentiniUCLA.
Alessandro S De NadaiUniversity of South Florida.
Elysse ArnoldUniversity of South Florida.
Adam B LewinUniversity of South Florida.
Tanya K MurphyUniversity of South Florida.
Eric A StorchUniversity of South Florida.
UCLA Health · USUniversity of South Florida · USUniversity of Miami · US

Funding

1/3 CBT for Anxiety Disorders in Autism: Adapting Treatment for AdolescentsR34HD065270 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOOD, JEFFREY JAMES · 2009 to 2010
$507k
NICHD NIH HHS R34 HD065270
6 · The paper itself

Abstract

Clinically elevated anxiety is a common, impairing feature of autism spectrum disorders (ASD). A modular CBT program designed for preteens with ASD, Behavioral Interventions for Anxiety in Children with Autism (BIACA; Wood et al., 2009) was enhanced and modified to address the developmental needs of early adolescents with ASD and clinical anxiety. Thirty-three adolescents (11-15 years old) were randomly assigned to 16 sessions of CBT or an equivalent waitlist period. The CBT model emphasized exposure, challenging irrational beliefs, and behavioral supports provided by caregivers, as well as numerous ASD-specific treatment elements. Independent evaluators, parents, and adolescents rated symptom severity at baseline and posttreatment/postwaitlist. In intent-to-treat analyses, the CBT group outperformed the waitlist group on independent evaluators' ratings of anxiety severity on the Pediatric Anxiety Rating Scale (PARS) and 79% of the CBT group met Clinical Global Impressions-Improvement scale criteria for positive treatment response at posttreatment, as compared to only 28.6% of the waitlist group. Group differences were not found for diagnostic remission or questionnaire measures of anxiety. However, parent-report data indicated that there was a positive treatment effect of CBT on autism symptom severity. The CBT manual under investigation, enhanced for early adolescents with ASD, yielded meaningful treatment effects on the primary outcome measure (PARS), although additional developmental modifications to the manual are likely warranted. Future studies examining this protocol relative to an active control are needed.

Indexed as

AdolescentAnxiety DisordersChildChild Development Disorders, PervasiveCognitive Behavioral TherapyDiagnostic and Statistical Manual of Mental DisordersFamily TherapyFemaleFollow-Up StudiesHumansMaleNeuropsychological TestsParentsPsychiatric Status Rating ScalesTreatment Outcomeanxiety disordersautism spectrum disorderscognitive behavioral therapyparent-training

Identifiers

PMID25526831
PMCPMC4272761
OpenAlexW2015814763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.