ArticleAmerican journal of physiology. Lung cellular and molecular physiology2015
Space radiation-associated lung injury in a murine model.
Article in American journal of physiology. Lung cellular and molecular physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 41 citations in OpenAlex.
- Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming.Radiation and environmental biophysics · 2025Article
- Potential Health Impacts, Treatments, and Countermeasures of Martian Dust on Future Human Space Exploration.GeoHealth · 2025Review
- Irradiation and Alterations in Hippocampal DNA Methylation.Epigenomes · 2024Review
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Radiation makes cells select the form of death dependent on external or internal exposure: apoptosis or pyroptosis.Scientific reports · 2023Article
- Pathological observation of the effects of exposure to radioactive microparticles on experimental animals.Journal of radiation research · 2022Review
- Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice.Journal of radiation research · 2021Article
- Low-dose radiotherapy for COVID-19 pneumonia treatment: case report, procedure, and literature review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020Review
- Impact of Local High Doses of Radiation by Neutron Activated Mn Dioxide Powder in Rat Lungs: Protracted Pathologic Damage Initiated by Internal Exposure.Biomedicines · 2020Article
- Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways.International journal of molecular sciences · 2020Review
- Iron and Sphingolipids as Common Players of (Mal)Adaptation to Hypoxia in Pulmonary Diseases.International journal of molecular sciences · 2020Review
- Short-term exposures to particulate matter gamma radiation activities and biomarkers of systemic inflammation and endothelial activation in COPD patients.Environmental research · 2020Article
- Pulmonary challenges of prolonged journeys to space: taking your lungs to the moon.The Medical journal of Australia · 2019Review
- LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.International journal of molecular sciences · 2019Article
- Effects of Iron Overload and Oxidative Damage on the Musculoskeletal System in the Space Environment: Data from Spaceflights and Ground-Based Simulation Models.International journal of molecular sciences · 2018Review
- DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives.Critical reviews in oncogenesis · 2018Review
- Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.International journal of molecular sciences · 2017Article
- The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment.International journal of molecular sciences · 2017Review
- Role of apoptosis and autophagy in tuberculosis.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight.Aerospace medicine and human performance · 2017Review
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
Despite considerable progress in identifying health risks to crewmembers related to exposure to galactic/cosmic rays and solar particle events (SPE) during space travel, its long-term effects on the pulmonary system are unknown. We used a murine risk projection model to investigate the impact of exposure to space-relevant radiation (SR) on the lung. C3H mice were exposed to (137)Cs gamma rays, protons (acute, low-dose exposure mimicking the 1972 SPE), 600 MeV/u (56)Fe ions, or 350 MeV/u (28)Si ions at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. Animals were irradiated at the age of 2.5 mo and evaluated 23.5 mo postirradiation, at 26 mo of age. Compared with age-matched nonirradiated mice, SR exposures led to significant air space enlargement and dose-dependent decreased systemic oxygenation levels. These were associated with late mild lung inflammation and prominent cellular injury, with significant oxidative stress and apoptosis (caspase-3 activation) in the lung parenchyma. SR, especially high-energy (56)Fe or (28)Si ions markedly decreased sphingosine-1-phosphate levels and Akt- and p38 MAPK phosphorylation, depleted anti-senescence sirtuin-1 and increased biochemical markers of autophagy. Exposure to SR caused dose-dependent, pronounced late lung pathological sequelae consistent with alveolar simplification and cellular signaling of increased injury and decreased repair. The associated systemic hypoxemia suggested that this previously uncharacterized space radiation-associated lung injury was functionally significant, indicating that further studies are needed to define the risk and to develop appropriate lung-protective countermeasures for manned deep space missions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.