ArticlePloS one2014
Engineering an endothelialized vascular graft: a rational approach to study design in a non-human primate model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Concise Review: Patency of Small-Diameter Tissue-Engineered Vascular Grafts: A Meta-Analysis of Preclinical Trials.Stem cells translational medicine · 2019Pooled it
- Micropatterning transcriptionally and phenotypically reprograms endothelial cells.Acta biomaterialia · 2026Article
- Thrombogenicity of biodegradable metals.Bioactive materials · 2024Article
- Pharmacologic targeting of coagulation factors XII and XI by monoclonal antibodies reduces thrombosis in nitinol stents under flow.Journal of thrombosis and haemostasis : JTH · 2024Article
- A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling.Bioactive materials · 2023Article
- The Effects of Topographic Micropatterning on Endothelial Colony-Forming Cells.Tissue engineering. Part A · 2021Article
- Evaluation of the Effect of Crosslinking Method of Poly(Vinyl Alcohol) Hydrogels on Thrombogenicity.Cardiovascular engineering and technology · 2020Article
- Quantifying Physical Thrombus Characteristics on Cardiovascular Biomaterials Using MicroCT.Methods and protocols · 2020Article
- Biomimetic modification of poly(vinyl alcohol): Encouraging endothelialization and preventing thrombosis with antiplatelet monotherapy.Acta biomaterialia · 2019Article
- Luminal Plasma Treatment for Small Diameter Polyvinyl Alcohol Tubular Scaffolds.Frontiers in bioengineering and biotechnology · 2019Article
- Static spatial growth restriction micropatterning of endothelial colony forming cells influences their morphology and gene expression.PloS one · 2019Article
- Reactive Ion Plasma Modification of Poly(Vinyl-Alcohol) Increases Primary Endothelial Cell Affinity and Reduces Thrombogenicity.Macromolecular bioscience · 2018Article
- Design of in situ porcine closed-circuit system for assessing blood-contacting biomaterials.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Article
- Improving Surgical Methods for Studying Vascular Grafts in Animal Models.Tissue engineering. Part C, Methods · 2018Article
- Thrombogenicity of flow diverters in an ex vivo shunt model: effect of phosphorylcholine surface modification.Journal of neurointerventional surgery · 2017Article
- In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Bioactive Anti-Thrombotic Modification of Decellularized Matrix for Vascular Applications.Advanced healthcare materials · 2016Article
- In vitro and ex vivo hemocompatibility of off-the-shelf modified poly(vinyl alcohol) vascular grafts.Acta biomaterialia · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
After many years of research, small diameter, synthetic vascular grafts still lack the necessary biologic integration to perform ideally in clinical settings. Endothelialization of vascular grafts has the potential to improve synthetic graft function, and endothelial outgrowth cells (EOCs) are a promising autologous cell source. Yet no work has established the link between endothelial cell functions and outcomes of implanted endothelialized grafts. This work utilized steady flow, oscillatory flow, and tumor necrosis factor stimulation to alter EOC phenotype and enable the formulation of a model to predict endothelialized graft performance. To accomplish this, EOC in vitro expression of coagulation and inflammatory markers was quantified. In parallel, in non-human primate (baboon) models, the platelet and fibrinogen accumulation on endothelialized grafts were quantified in an ex vivo shunt, or the tissue ingrowth on implanted grafts were characterized after 1mth. Oscillatory flow stimulation of EOCs increased in vitro coagulation markers and ex vivo platelet accumulation. Steady flow preconditioning did not affect platelet accumulation or intimal hyperplasia relative to static samples. To determine whether in vitro markers predict implant performance, a linear regression model of the in vitro data was fit to platelet accumulation data-correlating the markers with the thromboprotective performance of the EOCs. The model was tested against implant intimal hyperplasia data and found to correlate strongly with the parallel in vitro analyses. This research defines the effects of flow preconditioning on EOC regulation of coagulation in clinical vascular grafts through parallel in vitro, ex vivo, and in vivo analyses, and contributes to the translatability of in vitro tests to in vivo clinical graft performance.
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