ArticlePloS one2014
Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
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- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Development of a novel rodent rapid serial visual presentation task reveals dissociable effects of stimulant versus nonstimulant treatments on attentional processes.Cognitive, affective & behavioral neuroscience · 2024Article
- The Relationship between Executive Functions and Body Weight: Sex as a Moderating Variable.Behavioral sciences (Basel, Switzerland) · 2024Article
- Sex-Dependent Attentional Impairments in a Subchronic Ketamine Mouse Model for Schizophrenia.Biological psychiatry global open science · 2024Article
- MK-801 and cognitive functions: Investigating the behavioral effects of a non-competitive NMDA receptor antagonist.Psychopharmacology · 2023Review
- Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats.Psychopharmacology · 2022Article
- Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation.Neurobiology of stress · 2022Review
- Control of impulsivity by GCommunications biology · 2021Article
- Low Doses of Psilocybin and Ketamine Enhance Motivation and Attention in Poor Performing Rats: Evidence for an Antidepressant Property.Frontiers in pharmacology · 2021Article
- Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task.Psychopharmacology · 2020Article
- Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Profile of cortical N-methyl-D-aspartate receptor subunit expression associates with inherent motor impulsivity in rats.Biochemical pharmacology · 2019Article
- General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.Neuropharmacology · 2019Article
- Let's call the whole thing off: evaluating gender and sex differences in executive function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Prefrontal cortex executive processes affected by stress in health and disease.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task.Psychopharmacology · 2018Article
- Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2017Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
The 5-choice serial reaction time task (5CSRTT) has been widely used to study attention and impulse control in rodents. In order to mimic cognitive impairments in psychiatry, one approach has been to use acute administration of NMDA antagonists. This disruption in glutamatergic transmission leads to impairments in accuracy, omissions, and premature responses although findings have been inconsistent. In this study, we further investigated glutamatergic mechanisms using a novel version of the 5CSRTT, which we have previously shown to be more sensitive to cognitive enhancers. We first investigated the effects of systemic treatment with NMDA antagonists. We also carried out a preliminary investigation using targeted medial prefrontal cortex infusions of a NMDA antagonist (MK801), mGluR2/3 antagonist (LY341495), and mGluR7 negative allosteric modulator (MMPIP). Acute systemic administration of the different NMDA antagonists had no specific effects on accuracy. At higher doses PCP, ketamine, and memantine, increased omissions and affected other measures suggesting a general disruption in task performance. Only MK801 increased premature responses, and reduced omissions at lower doses suggesting stimulant like effects. None of the NMDA antagonists affected accuracy or any other measures when tested using a short stimulus challenge. Infusions of MK801 had no effect on accuracy but increased premature responses following infralimbic, but not prelimbic infusion. LY341495 had no effects in either brain region but a decrease in accuracy was observed following prelimbic infusion of MMPIP. Contrary to our hypothesis, disruptions to glutamate transmission using NMDA antagonists did not induce any clear deficits in accuracy in this modified version of the 5CSRTT. We also found that the profile of effects for MK801 differed from those observed with PCP, ketamine, and memantine. The effects of MK801 in the infralimbic cortex add to the literature indicating this brain region and glutamate play an important role in impulse control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.