ArticleThe American journal of psychiatry2015
Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events.
Article in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- Stressful life events during adolescence and risk for externalizing and internalizing psychopathology: a meta-analysis.European child & adolescent psychiatry · 2017Pooled it
- You say 'prefrontal cortex' and I say 'anterior cingulate': meta-analysis of spatial overlap in amygdala-to-prefrontal connectivity and internalizing symptomology.Translational psychiatry · 2016Pooled it
- An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?Development and psychopathology · 2018Trial
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression - An IDEA RiSCo prospective cohort study.Molecular psychiatry · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Chronic adolescent stress attenuates morphine-induced antinociception and central amygdala neuronal activation in adult Wistar rats.Physiology & behavior · 2025Article
- Family History of Substance Use and Stressful Life Events Impact Adolescent Maturation of Cerebral White Matter.Addiction biology · 2025Article
- Mechanistic intersections between migraine and major depressive disorder.The journal of headache and pain · 2025Review
- Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort.Biological psychiatry global open science · 2025Article
- Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood.JCPP advances · 2024Article
- Friendship changes differentially predict neural correlates of decision-making for friends across adolescence.Developmental cognitive neuroscience · 2024Article
- Associations between perceived parenting, brain activity and connectivity, and depression symptoms in Brazilian adolescents.International journal of adolescence and youth · 2024Article
- Closed-loop neurostimulation for the treatment of psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- A precision neuroscience approach to estimating reliability of neural responses during emotion processing: Implications for task-fMRI.NeuroImage · 2024Article
- Neural patterns of threat response in adolescents predict vulnerability for and resilience against internalizing symptoms during COVID-19 waves.Neuroimage. Reports · 2023Article
- Neural activation to peer acceptance and rejection in relation to concurrent and prospective depression risk in adolescent and pre-adolescent girls.Biological psychology · 2023Article
- Impact of Perceived Body Weight on Depression, Anxiety and Stress Levels of Young Adults in Turkey.Iranian journal of public health · 2023Article
- Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents.Brain, behavior, and immunity · 2022Article
- Brain morphometry and connectivity differs between adolescent- and adult-onset major depressive disorder.Depression and anxiety · 2022Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAlthough heightened amygdala reactivity is observed in patients with major depression, two critical gaps in our knowledge remain. First, it is unclear whether heightened amygdala reactivity is a premorbid vulnerability or a consequence of the disorder. Second, it is unknown how and when this neural phenotype develops. The authors sought to address these gaps by evaluating developmental change in threat-related amygdala reactivity in adolescents at high or low risk for depression based on family history, before onset of disorder.
methodAt baseline and again 2 years later, adolescents (initially 11-15 years of age) participated in a functional MRI paradigm that elicited threat-related amygdala reactivity. After quality control, data were available for 232 adolescents at wave 1 and 197 adolescents at wave 2; longitudinal data meeting quality control at both waves were available for 157 of these participants. Change in amygdala reactivity was assessed as a function of family history of depression and severity of stressful life events.
resultsThreat-related amygdala reactivity increased with age in participants with a positive family history regardless of the severity of life stress reported, and it increased in adolescents with a negative family history who reported relatively severe life stress. These changes in amygdala reactivity with age occurred in the absence of clinical disorder or increases in depressive symptoms.
conclusionsThese results suggest that heightened amygdala reactivity emerges during adolescence, prior to the development of depression, as a function of familial risk or, in the absence of familial risk, stressful life events.
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