ArticleInternational journal of molecular sciences2014
The dynamics of DNA methylation in maize roots under Pb stress.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Genome-Wide Identification and Functional Analysis of DNA Methylation-Related Genes inPlants (Basel, Switzerland) · 2026Article
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- Melatonin improves the lead tolerance in Plantago ovata by modulating ROS homeostasis, phytohormone status and expression of stress-responsive genes.Plant cell reports · 2025Article
- Article
- Impact of Abiotic Stress on Rice and the Role of DNA Methylation in Stress Response Mechanisms.Plants (Basel, Switzerland) · 2024Review
- Unravelling the Epigenetic Code: DNA Methylation in Plants and Its Role in Stress Response.Epigenomes · 2024Review
- Epigenetic Control of Plant Response to Heavy Metals.Plants (Basel, Switzerland) · 2023Review
- Physiological and molecular response and tolerance of Macleaya cordata to lead toxicity.BMC genomics · 2023Article
- DNA Methylation in Plant Responses and Adaption to Abiotic Stresses.International journal of molecular sciences · 2022Review
- Epigenetic control of abiotic stress signaling in plants.Genes & genomics · 2022Review
- DNA methylation and histone modifications induced by abiotic stressors in plants.Genes & genomics · 2022Review
- Reactive Oxygen Species Partly Mediate DNA Methylation in Responses to Different Heavy Metals in Pokeweed.Frontiers in plant science · 2022Article
- Recent advances in physiological and molecular mechanisms of heavy metal accumulation in plants.Environmental science and pollution research international · 2021Review
- Vineyard environments influence Malbec grapevine phenotypic traits and DNA methylation patterns in a clone-dependent way.Plant cell reports · 2021Article
- Increased epigenetic diversity and transient epigenetic memory in response to salinity stress inEcology and evolution · 2020Article
- Differential expression pattern of the proteome in response to cadmium stress based on proteomics analysis of wheat roots.BMC genomics · 2020Article
- Epigenomic landscape and epigenetic regulation in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Review
- Changes of DNA methylation of Isoetes sinensis under Pb and Cd stress.Environmental science and pollution research international · 2019Article
- Genome-Wide Characterization of DNA Demethylase Genes and Their Association with Salt Response in Pyrus.Genes · 2018Article
- Genome-wide association analysis of lead accumulation in maize.Molecular genetics and genomics : MGG · 2018Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants adapt to adverse conditions through a series of physiological, cellular, and molecular processes, culminating in stress tolerance. However, little is known about the associated regulatory mechanisms at the epigenetic level in maize under lead (Pb) stress. Therefore, in this study, we aimed to compare DNA methylation profiles during the dynamic development of maize roots following Pb treatment to identify candidate genes involved in the response to Pb stress. Methylated DNA immunoprecipitation-sequencing (MeDIP-seq) was used to investigate the genome-wide DNA methylation patterns in maize roots under normal condition (A1) and 3 mM Pb(NO3)2 stress for 12 h (K2), 24 h (K3) and 48 h (K4). The results showed that the average methylation density was the highest in CpG islands (CGIs), followed by the intergenic regions. Within the gene body, the methylation density of the introns was higher than those of the UTRs and exons. In total, 3857 methylated genes were found in 4 tested samples, including 1805 differentially methylated genes for K2 versus A1, 1508 for K3 versus A1, and 1660 for K4 versus A1. Further analysis showed that 140 genes exhibited altered DNA methylation in all three comparisons, including some well-known stress-responsive transcription factors and proteins, such as MYB, AP2/ERF, bZIP, serine-threonine/tyrosine-proteins, pentatricopeptide repeat proteins, RING zinc finger proteins, F-box proteins, leucine-rich repeat proteins and tetratricopeptide repeat proteins. This study revealed the genome-scale DNA methylation patterns of maize roots in response to Pb exposure and identified candidate genes that potentially regulate root dynamic development under Pb stress at the methylation level.
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