ArticleThe ISME journal2015
Fundamental shift in vitamin B12 eco-physiology of a model alga demonstrated by experimental evolution.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 83 citations in OpenAlex.
- Multiomics studies reveal how ambient temperature changes govern cellular responses of Chlamydomonas.The Plant cell · 2026Article
- A cooperative cobalamide biosynthesis guild in the endosphere of the edible aquatic plant Wolffia globosa Mankai.Environmental microbiome · 2026Article
- Mono-mix strategy enables comparative proteomics of a cross-kingdom microbial symbiosis.PloS one · 2026Article
- The Corrinoid Model for Dissecting Microbial Community Interactions Across Scales.Annual review of microbiology · 2025Review
- Genome-Wide Adaptation to a Complex Environmental Gradient in a Keystone Phytoplankton Species.Molecular ecology · 2025Article
- Skin-associatedmSphere · 2025Article
- Microbial cross-feeding stabilized by segregation of a dependent mutant from its independent ancestor.The ISME journal · 2025Article
- Skin-associatedbioRxiv : the preprint server for biology · 2024Article
- A mutualistic bacterium rescues a green alga from an antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Exchange or Eliminate: The Secrets of Algal-Bacterial Relationships.Plants (Basel, Switzerland) · 2024Review
- Flexible BProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Conserved cobalamin acquisition protein 1 is essential for vitamin B12 uptake in both Chlamydomonas and Phaeodactylum.Plant physiology · 2024Article
- Scarcity of fixed carbon transfer in a model microbial phototroph-heterotroph interaction.The ISME journal · 2024Article
- Phylogenetic distribution and experimental characterization of corrinoid production and dependence in soil bacterial isolates.The ISME journal · 2024Article
- The Chlamydomonas Genome Project, version 6: Reference assemblies for mating-type plus and minus strains reveal extensive structural mutation in the laboratory.The Plant cell · 2023Article
- Review
- Phenotype stability and dynamics of transposable elements in a strain of the microalga Tisochrysis lutea with improved lipid traits.PloS one · 2023Article
- Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros.PLoS biology · 2022Article
- Vitamin BFundamental research · 2022Article
- Exploring the onset of BEnvironmental microbiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
A widespread and complex distribution of vitamin requirements exists over the entire tree of life, with many species having evolved vitamin dependence, both within and between different lineages. Vitamin availability has been proposed to drive selection for vitamin dependence, in a process that links an organism's metabolism to the environment, but this has never been demonstrated directly. Moreover, understanding the physiological processes and evolutionary dynamics that influence metabolic demand for these important micronutrients has significant implications in terms of nutrient acquisition and, in microbial organisms, can affect community composition and metabolic exchange between coexisting species. Here we investigate the origins of vitamin dependence, using an experimental evolution approach with the vitamin B(12)-independent model green alga Chlamydomonas reinhardtii. In fewer than 500 generations of growth in the presence of vitamin B(12), we observe the evolution of a B(12)-dependent clone that rapidly displaces its ancestor. Genetic characterization of this line reveals a type-II Gulliver-related transposable element integrated into the B(12)-independent methionine synthase gene (METE), knocking out gene function and fundamentally altering the physiology of the alga.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.