ArticlePloS one2014
Use of the zebrafish larvae as a model to study cigarette smoke condensate toxicity.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- E-Cigarette and Vanillin Exposure Disrupts Cardiovascular Development in Xenopus laevis.Birth defects research · 2025Article
- Benzo[a]pyrene in the Mainstream Smoke of Little Cigars.Chemical research in toxicology · 2025Article
- Zebrafish (International journal of molecular sciences · 2023Review
- Systemic treatment with cigarette smoke extract affects zebrafish visual behaviour, intraocular vasculature morphology and outer segment phagocytosis.Open research Europe · 2023Article
- Assessing the Morphological and Behavioral Toxicity of Catechol Using Larval Zebrafish.International journal of molecular sciences · 2022Article
- E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos.Developmental biology · 2022Article
- Zebrafish as an experimental model for the simulation of neurological and craniofacial disorders.Veterinary world · 2022Review
- Effect of Water-Pipe Smoking on the Normal Development of Zebrafish.International journal of environmental research and public health · 2021Article
- Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances.Toxics · 2021Article
- Exposure to the gut microbiota from cigarette smoke-exposed mice exacerbates cigarette smoke extract-induced inflammation in zebrafish larvae.Current research in immunology · 2021Article
- Article
- Melanogenic Inhibition and Toxicity Assessment of Flavokawain A and B on B16/F10 Melanoma Cells and Zebrafish (Molecules (Basel, Switzerland) · 2020Article
- Zebrafish Models of Craniofacial Malformations: Interactions of Environmental Factors.Frontiers in cell and developmental biology · 2020Review
- Adult and Developing Zebrafish as Suitable Models for Cardiac Electrophysiology and Pathology in Research and Industry.Frontiers in physiology · 2020Review
- A Novel In Vivo Model to Study Impaired Tissue Regeneration Mediated by Cigarette Smoke.Scientific reports · 2018Article
- Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development.Clinical and experimental otorhinolaryngology · 2018Article
- Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity.BioMed research international · 2018Review
- Adult zebrafish in CNS disease modeling: a tank that's half-full, not half-empty, and still filling.Lab animal · 2017Article
- Zebrafish as a Vertebrate Model System to Evaluate Effects of Environmental Toxicants on Cardiac Development and Function.International journal of molecular sciences · 2016Review
- Differences in cardiovascular toxicities associated with cigarette smoking and snuff use revealed using novel zebrafish models.Biology open · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The smoking of tobacco continues to be the leading cause of premature death worldwide and is linked to the development of a number of serious illnesses including heart disease, respiratory diseases, stroke and cancer. Currently, cell line based toxicity assays are typically used to gain information on the general toxicity of cigarettes and other tobacco products. However, they provide little information regarding the complex disease-related changes that have been linked to smoking. The ethical concerns and high cost associated with mammalian studies have limited their widespread use for in vivo toxicological studies of tobacco. The zebrafish has emerged as a low-cost, high-throughput, in vivo model in the study of toxicology. In this study, smoke condensates from 2 reference cigarettes and 6 Canadian brands of cigarettes with different design features were assessed for acute, developmental, cardiac, and behavioural toxicity (neurotoxicity) in zebrafish larvae. By making use of this multifaceted approach we have developed an in vivo model with which to compare the toxicity profiles of smoke condensates from cigarettes with different design features. This model system may provide insights into the development of smoking related disease and could provide a cost-effective, high-throughput platform for the future evaluation of tobacco products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.