ArticlePloS one2014
An improved model for the hTERT promoter quadruplex.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- Bioactive nutraceuticals as G4 stabilizers: potential cancer prevention and therapy-a critical review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Inhibited complete folding of consecutive human telomeric G-quadruplexes.Nucleic acids research · 2023Article
- Crosstalk between G-quadruplex and ROS.Cell death & disease · 2023Review
- Reactivation of telomerase reverse transcriptase expression in cancer: the role of TERT promoter mutations.Frontiers in cell and developmental biology · 2023Review
- Higher-order G-quadruplexes in promoters are untapped drug targets.Frontiers in chemistry · 2023Review
- G-Quadruplex Formed by the Promoter Region of theBiomedicines · 2022Article
- Affinity Chromatography-Based Assays for the Screening of Potential Ligands Selective for G-Quadruplex Structures.ChemistryOpen · 2022Article
- Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences.Nucleic acids research · 2022Article
- Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex.PloS one · 2022Article
- Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter.Oxidative medicine and cellular longevity · 2022Review
- Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives.International journal of molecular sciences · 2020Article
- Role of POT1 in Human Cancer.Cancers · 2020Review
- The hTERT core promoter forms three parallel G-quadruplexes.Nucleic acids research · 2020Article
- Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model.Nucleic acids research · 2020Article
- Human POT1 unfolds G-quadruplexes by conformational selection.Nucleic acids research · 2020Article
- Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology.ACS medicinal chemistry letters · 2020Article
- Oxidative Stress: Role and Response of Short Guanine Tracts at Genomic Locations.International journal of molecular sciences · 2019Review
- Structure and Function of Multimeric G-Quadruplexes.Molecules (Basel, Switzerland) · 2019Review
- Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress.Nucleic acids research · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic properties and stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.