ArticleInternational journal of environmental research and public health2014
Protective roles of sodium selenite against aflatoxin B1-induced apoptosis of jejunum in broilers.
Article in International journal of environmental research and public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Review
- Impact of Aflatoxins on the Digestive, Immune, and Nervous Systems: The Role of Microbiota and Probiotics in Toxicity Protection.International journal of molecular sciences · 2025Review
- Aflatoxin BOpen medicine (Warsaw, Poland) · 2024Review
- AflatoxinBVeterinary medicine and science · 2023Review
- Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers.BMC veterinary research · 2022Article
- Dietary Lycopene Supplementation Could Alleviate Aflatoxin BAnimals : an open access journal from MDPI · 2021Article
- Comparative consequences of two sources of aflatoxins in ducklings experimental aflatoxicosis.Veterinary research forum : an international quarterly journal · 2021Article
- Bio-protective effects ofCurrent medical mycology · 2020Article
- Review
- Ameliorative effects of selenium on the excess apoptosis of the jejunum caused by AFBToxicology research · 2018Article
- Mycotoxin: Its Impact on Gut Health and Microbiota.Frontiers in cellular and infection microbiology · 2018Review
- Aflatoxin BOncotarget · 2017Article
- A study on the expression of apoptotic molecules related to death receptor and endoplasmic reticulum pathways in the jejunum of AFBOncotarget · 2017Article
- Article
- Pathological Impairment, Cell Cycle Arrest and Apoptosis of Thymus and Bursa of Fabricius Induced by Aflatoxin-Contaminated Corn in Broilers.International journal of environmental research and public health · 2017Article
- The mitochondrial and endoplasmic reticulum pathways involved in the apoptosis of bursa of Fabricius cells in broilers exposed to dietary aflatoxin B1.Oncotarget · 2016Article
- The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B1.Oncotarget · 2016Article
- Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁.International journal of environmental research and public health · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of aflatoxin B1 (AFB1) exposure and sodium selenite supplementation on cell apoptosis of jejunum in broilers were studied. A total of 240 one-day-old male AA broilers were randomly assigned four dietary treatments containing 0 mg/kg of AFB1 (control), 0.3 mg/kg AFB1 (AFB1), 0.4 mg/kg supplement Se (+ Se) and 0.3 mg/kg AFB1 + 0.4 mg/kg supplement Se (AFB1 + Se), respectively. Compared with the control broilers, the number of apoptotic cells, the expression of Bax and Caspase-3 mRNA were significantly increased, while the expression of Bcl-2 mRNA and the Bcl-2/Bax ratio were significantly decreased in AFB1 broilers. The number of apoptotic cells and the expression of Caspase-3 mRNA in AFB1 + Se broilers were significantly higher than those in the control broilers, but significantly lower than those in AFB1 broilers. There were no significant changes in the expression of Bax mRNA between AFB1 + Se and control broilers; the expression of Bcl-2 mRNA and the Bcl-2/Bax ratio in AFB1 + Se broilers were significantly lower than those in the control broilers, but significantly higher than those in AFB1 broilers. In conclusion, 0.3 mg/kg AFB1 in the diet can increase cell apoptosis, decrease Bcl-2 mRNA expression, and increase of Bax and Caspase-3 mRNA expression in broiler's jejunum. However, supplementation of dietary sodium selenite at the concentration of 0.4 mg/kg Se may ameliorate AFB1-induced apoptosis by increasing Bcl-2 mRNA expression, and decreasing Bax and Caspase-3 mRNA expression.
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