Evidence map›Paper›PMID 25525786›Full record

ArticleCell host & microbe2014

Dynamic intervention: pathogen disarmament of mitochondrial-based immune surveillance.

Robin L Holland, Steven R Blanke

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell host & microbe, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Robin L HollandDepartment of Microbiology, University of Illinois, Urbana, IL 61801, USA.
Steven R BlankeDepartment of Microbiology, University of Illinois, Urbana, IL 61801, USA. Electronic address: sblanke@illinois.edu.

Funding

MOLECULAR MECHANISMS OF THE H. PYLORI VACUOLATING TOXINR01AI045928 · NIAID · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI BLANKE, STEVEN R. · 2000 to 2010
$1.9M
NIAID NIH HHS R01 AI045928NIGMS NIH HHS T32 GM078876-01
6 · The paper itself

Abstract

In this issue of Cell Host & Microbe, Suzuki et al. (2014) describe a Vibrio cholerae Type-III-secreted effector that targets mitochondrial dynamics to dampen host innate immune signaling. This suggests that mammalian hosts possess surveillance mechanisms to monitor pathogen-mediated alterations in the integrity of normal cellular processes and organelles.

Indexed as

Bacterial Secretion SystemsImmunity, InnateAnimalsBacterial ProteinsHumansMitochondrial Dynamicsrho GTP-Binding ProteinsVibrio choleraeBacterial ProteinsBacterial Secretion Systemsrho GTP-Binding Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.